Similar duration of viral shedding of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) delta variant between vaccinated and incompletely vaccinated individuals

Article Infectious Diseases

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study

Po Ying Chia et al.

Summary: This study found that mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection. Vaccination is associated with a faster decline in viral RNA load and a robust serological response.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Immunology

Surface and Air Contamination With Severe Acute Respiratory Syndrome Coronavirus 2 From Hospitalized Coronavirus Disease 2019 Patients in Toronto, Canada, March-May 2020

Jonathon D. Kotwa et al.

Summary: The infrequent recovery of infectious SARS-CoV-2 virus from the environment suggests that the risk to healthcare workers from air and near-patient surfaces in acute care hospital wards is likely limited.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

Anika Singanayagam et al.

Summary: Vaccination reduces the risk of delta variant infection and accelerates viral clearance. However, fully vaccinated individuals with breakthrough infections may still have similar peak viral loads as unvaccinated cases and can efficiently transmit the infection.

LANCET INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2

Olha Puhach et al.

Summary: The infectious viral load of SARS-CoV-2 Omicron BA.1 is lower than that of Delta in breakthrough infections of vaccinated individuals. Vaccines may lower transmission risk and have a public health benefit.

NATURE MEDICINE (2022)

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Article Medicine, General & Internal

Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada

David N. Fisman et al.

Summary: Research in Ontario, Canada, showed that new variants of concern (VOCs) of SARS-CoV-2 have higher risks of hospitalization, ICU admission, and death compared to non-VOC strains, with the Delta variant showing the most pronounced increase in risk.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Public, Environmental & Occupational Health

Detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in outpatients: A multicenter comparison of self-collected saline gargle, oral swab, and combined oral-anterior nasal swab to a provider collected nasopharyngeal swab

Christopher E. Kandel et al.

Summary: The study found that self-collected saline gargle and oral-anterior nasal swab have a similar sensitivity to a nasopharyngeal swab for the detection of SARS-CoV-2, eliminating barriers to testing.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2021)

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Letter Medicine, General & Internal

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons

Stephen M. Kissler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies

Stephen M. Kissler et al.

Summary: The study analyzed the viral RNA trajectories for 68 individuals during the resumption of the NBA season, finding that viral RNA concentrations typically peak 3.3 days after the onset of infection, with differences in the duration of the clearance phase between symptomatic and asymptomatic individuals. A second test within 2 days after an initial positive PCR test improves certainty about the infection stage, and the sensitivity of tests decreases with longer turnaround times.

PLOS BIOLOGY (2021)

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Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

Muge Cevik et al.

Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

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Review Infectious Diseases

SARS-CoV-2 detection, viral load and infectivity over the course of an infection

Kieran A. Walsh et al.

JOURNAL OF INFECTION (2020)

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Similar duration of viral shedding of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) delta variant between vaccinated and incompletely vaccinated individuals

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