期刊
INDOOR AIR
卷 32, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/ina.13029
关键词
Air change rate; Airborne transmission; COVID-19 pandemic; COVID-19 symptoms; PTFE filter virus sampling; SARS-CoV-2 aerosols
类别
资金
- NIEHS P30 Center [ES05022]
- NIH/CATS [UL1TR003017]
- NIEHS Training Grant in Exposure Science [1T32ES019854]
- NIOSH ERC [T42OH008422]
This study suggests that using portable air cleaners (PACs) with HEPA filters can reduce the risk of airborne transmission of SARS-CoV-2 in residences. The results show a significant decrease in positive aerosol samples when the PAC is operated at its lowest setting.
Individuals with COVID-19 who do not require hospitalization are instructed to self-isolate in their residences. Due to high secondary infection rates in household members, there is a need to understand airborne transmission of SARS-CoV-2 within residences. We report the first naturalistic intervention study suggesting a reduction of such transmission risk using portable air cleaners (PACs) with HEPA filters. Seventeen individuals with newly diagnosed COVID-19 infection completed this single-blind, crossover, randomized study. Total and size-fractionated aerosol samples were collected simultaneously in the self-isolation room with the PAC (primary) and another room (secondary) for two consecutive 24-h periods, one period with HEPA filtration and the other with the filter removed (sham). Seven out of sixteen (44%) air samples in primary rooms were positive for SARS-CoV-2 RNA during the sham period. With the PAC operated at its lowest setting (clean air delivery rate [CADR] = 263 cfm) to minimize noise, positive aerosol samples decreased to four out of sixteen residences (25%; p = 0.229). A slight decrease in positive aerosol samples was also observed in the secondary room. As the world confronts both new variants and limited vaccination rates, our study supports this practical intervention to reduce the presence of viral aerosols in a real-world setting.
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