Imaging in Pediatric Obstructive Jaundice

Cholestatic jaundice characterized by elevated conjugated bilirubin can be due to multitude of factors in neonates and childhood. Extrahepatic biliary atresia (EHBA), choledochal cyst, neonatal hepatitis, cytomegalovirus (CMV), and biliary plug are some of the common causes in neonate and early infancy. Causes in late infancy and childhood comprises viral hepatitis, choledochal cyst, cholelithiasis, worm infestation, and biliary compression secondary to extrinsic causes (node, collection, tumor). Some serious disorders like biliary atresia must be considered with the emphasis on early diagnosis of treatable causes. In the modern era, with multiple diagnostic modalities available including high-resolution ultrasonography, magnetic resonance imaging (MRI), CT scan, and nuclear imaging [hepatobiliary iminodiacetic acid (HIDA) scan], rapid diagnosis can be made in many surgically treatable cases. The authors will discuss the imaging modality available with advantages, disadvantages, and common indications of each modality, and overview of obstructive jaundice discussing the wide spectrum of causes in neonates and late childhood. Combining available knowledge with careful and meticulous search can help narrow down the diagnosis and initiate prompt treatment.

Automated summary

Cholestatic jaundice with elevated conjugated bilirubin can have various causes in neonates and children. In neonates, common causes include extrahepatic biliary atresia, choledochal cyst, neonatal hepatitis, cytomegalovirus infection, and biliary plug. In late infancy and childhood, viral hepatitis, choledochal cyst, cholelithiasis, worm infestation, and biliary compression due to external causes are common. Early diagnosis is important for treatable causes, and modern diagnostic modalities can aid in rapid diagnosis and surgical treatment.