期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 204, 期 -, 页码 219-225出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2016.06.049
关键词
Brain; Grey matter; White matter; Depression; Magnetic resonance imaging
资金
- MRC Lifelong Health and Wellbeing' Program Grant (UK Medical Research Council) [G1001354]
- Gordon Edward Small's Charitable Trust [SC008962]
- HDH Wills Charitable Trust (PI: KPE)
- National Institute of Health Research
- Wolfson College
- Oxford and Oxford University Clinical Academic Graduate School
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust
- University of Oxford
- HDH Wills Charitable Trust
- National Institute on Aging, NIH [R01AG013196, R01AG034454]
- UK Medical Research Council [G1001354, K013351]
- US National Institutes of Health [R01AG034454, R01HL036310]
- ESRC professorship
- British Heart Foundation [RG/13/2/30098] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1] Funding Source: researchfish
- Medical Research Council [MR/L023784/1, MR/L023784/2, MR/K013351/1, G1001354, MR/M024962/1, MC_EX_MR/N50192X/1] Funding Source: researchfish
- Parkinson's UK [J-1403] Funding Source: researchfish
- Stroke Association [TSA2008/05] Funding Source: researchfish
- ESRC [ES/J023299/1] Funding Source: UKRI
- MRC [MR/M024962/1, G1001354, MR/L023784/1, MR/K013351/1, MR/L023784/2, MC_EX_MR/N50192X/1] Funding Source: UKRI
Background: Late-life sub-threshold depressive symptoms (i.e. depressive symptoms that do not meet the criteria for a diagnosis of major depressive disorder) are associated with impaired physical health and function, and increased risk of major depressive disorder. Magnetic resonance imaging (MRI) studies examining late-life major depressive disorder find structural brain changes in grey and white matter. However, the extent to which late-life sub-threshold depression is associated with similar hallmarks is not well established. Methods: Participants with no history of major depressive disorder were selected from the Whitehall Imaging Sub-Study (n = 358, mean age 69 +/- 5 years, 17% female). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression Scale (CES-D) at three previous Whitehall II Study phases (2003-04, 2007-09 and 2012-13) and at the time of the MRI scan (2012-14). The relationships between current and cumulative depressive symptoms and MRI brain measures were explored using Voxel-Based Morphometry (VBM) for grey matter and Tract Based Spatial Statistics (TBSS) for white matter. Results: Current sub-threshold depressive symptoms were associated with significant reductions in fractional anisotropy and increases in axial and radial diffusivity. There were no significant relationships between current depressive symptoms and grey matter measures, or cumulative depressive symptoms and MRI measures. Limitations: The prevalence (10%) of sub-threshold depressive symptoms means that analyses may be underpowered to detect subtle differences in brain structure. Conclusions: Current sub-threshold depressive symptoms are associated with changes in white matter microstructure, indicating that even mild depressive symptoms are associated with similar MRI hall-marks to those in major depressive disorder. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据