期刊
IEEE TRANSACTIONS ON MEDICAL IMAGING
卷 41, 期 4, 页码 782-792出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2021.3123912
关键词
Ultrasonic imaging; Ultrasonic variables measurement; Arteries; Velocity measurement; Rats; Mice; Imaging; Non-invasive in-depth transcranial brain imaging; cerebral microvascular pulsatile flow; pulsatility index; microbubbles; dynamic ultrasound localization microscopy
类别
资金
- Institute for Data Valorization (IVADO)
- Canada Foundation for Innovation [38095]
- New Frontiers in Research Fund [NFRFE-2018-01312]
- IVADO
- TransMedTech Institute
- Fonds de recherche du Quebec-Nature et technologies
- Quebec Bio-Imaging Network
- Canada First Research Excellence Fund (Apogee/CFREF)
Increased pulse pressure from arterial stiffening and cardiovascular disease may cause brain damage and cognitive decline. DULM, a novel imaging approach, can provide high-resolution imaging of pulsatility propagation in the whole rodent brain, improving our understanding of the link between pulsatility and cognitive decline.
An increased pulse pressure, due to arteries stiffening with age and cardiovascular disease, may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide imaging of the pulsatility propagation from main feeding arteries to capillaries in small animals could improve our understanding of the link between pulsatility and cognitive decline. However, it requires higher spatiotemporal resolution and penetration depth than currently available with existing brain imaging techniques. Herein, we show the feasibility of performing Dynamic Ultrasound Localization Microscopy (DULM), a novel imaging approach to capture hemodynamics with a subwavelength resolution. By producing cine-loops of flowing microbubbles in 2D in the whole rodent brain lasting several cardiac cycles, DULM performed pulsatility measurements in microvessels in-depth, in vivo, with and without craniotomy. Cortical veins and arteries were shown to have a significatively different pulsatility index and the method was compared against Contrast Enhanced Ultrafast Ultrasound Doppler (CEUFD) pulsatility measurements.
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