期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 91, 期 -, 页码 3-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.01.002
关键词
EPR effect artifacts; EPR effect dynamics; EPR effect dependence on time and molecular size; Nanomedicines; Macromolecular drugs; Anticancer drugs
资金
- Government of Japan from MEXT [08011717]
- MHLW [H23-3rd Cancer Project-General-001]
The enhanced permeability and retention (EPR) effect of solid tumors as seen with nanomedicines and macromolecular drugs is well known. However, many researchers appear to lack a full understanding of this effect. The effect varies depending on a patient's pathological and physiological characteristics and clinical condition. When a patient's systolic blood pressure is low side of about 90 mm Hg instead of 120-130 mm Hg, the hydrodynamic force pushing blood from the luminal side of a vessel into tumor tissue becomes significantly low, which results in a low EPR. Also, a vascular embolism in a tumor may impede blood flow and the EPR. Here, I describe the background of the EPR effect, heterogeneity of this effect, physiological and pathological factors affecting the effect, the EPR effect in metastatic tumors, artifacts of the EPR effect with micellar and liposomal drugs, problems of macromolecular drug stability and drug release, and access to target sites. (C) 2015 Elsevier B.V. All rights reserved.
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