☆ 4.2 Article

HLA-E01:01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E01:03 allele increases the resistance to anti-HCV treatments in frequently transfused thalassemia patients

HUMAN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Identification of a novel replication-competent hepatitis C virus variant that confers the sofosbuvir resistance

Steve Leumi et al.

Summary: Despite the excellent antiviral potency of direct-acting antivirals (DAAs) against hepatitis C virus (HCV), drug-resistant viral mutations remain a potential challenge. This study identified the combination of two NS5B mutations, S282T and K74R, as a novel resistance-associated substitution (RAS) that confers substantial resistance to SOF while retaining the HCV replication capacity.

ANTIVIRAL RESEARCH (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Sofosbuvir/velpatasvir with or without low-dose ribavirin for patients with chronic hepatitis C virus infection and severe renal impairment

Chen-Hua Liu et al.

Summary: In patients with severe renal impairment and chronic hepatitis C virus infection, sofosbuvir/velpatasvir (SOF/VEL) with or without low-dose ribavirin (RBV) for 12 weeks showed high effectiveness and safety, with high sustained virological response rates and minimal adverse events.

GUT (2022)

添加到收藏夹

Review Immunology

Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice

Mehran Ghasemzadeh et al.

Summary: The COVID-19 virus disrupts immune responses by interfering with the cytolytic antiviral effects of NK cells and activating immune cells, leading to a dangerous cytokine storm. Improving the cytotoxicity of NK cells may benefit treatment protocols, and the clonal expansion of activating NK memory cells holds promise for vaccine development and NK cell therapy in COVID-19.

HUMAN IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV

Giulia Morsica et al.

Summary: This study retrospectively evaluated the dynamics of HIV viral load in HIV/HCV patients treated with direct acting antivirals (DAAs). The results showed that the presence of baseline HIV residual viremia, previous virological blips, the number of failed ART regimens before DAAs initiation, and age were significantly associated with HIV virological failure.

PLOS ONE (2022)

添加到收藏夹

Review Infectious Diseases

Antivirals against HCV infection: the story thus far

Ahmad Adebayo Irekeola et al.

Summary: Remarkable scientific breakthroughs have been made in the development of anti-HCV regimens, leading to the transition from interferon-based treatments to all-oral interferon-free regimens. Despite some drugs still under development, several have been approved and shown high sustained virologic response rates of > 90%. However, achieving the WHO global target of eliminating hepatitis C as a public health problem by 2030 remains uncertain.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

HIV-reservoir size is not affected either by HCV coinfection or by direct acting antivirals (DAAs) therapy

Beatriz Alvarez et al.

Summary: This study assessed the impact of HCV eradication on HIV-DNA content in HIV/HCV-coinfected patients treated with direct-acting antivirals. The results suggest that HCV does not influence the size of the HIV reservoir and that DAAs do not have an anti-HIV action.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Microbiology

Identifying Different Mutation Sites Leading to Resistance to the Direct-Acting Antiviral (DAA) Sofosbuvir in Hepatitis C Virus Patients from Egypt

Aly Atef Shoun et al.

Summary: This study investigated the genotype and structural analysis of patients with genotype 4a hepatitis C virus (HCV) infections who failed to respond to sofosbuvir treatment. The presence of mutation sites and amino acid substitutions associated with resistance to sofosbuvir was identified. The results highlight the significant impact of these mutations on the resistance of the HCV NS5B RNA-dependent RNA polymerase to direct-acting antivirals.

MICROORGANISMS (2022)

添加到收藏夹

Article Immunology

HLA-E gene polymorphisms in chronic hepatitis C: Impact on HLA-E liver expression and disease severity

Roberta Chaves Araujo et al.

Summary: The study investigated the impact of HLA-E gene polymorphisms on HLA-E liver expression and severity of hepatitis C, revealing associations between specific HLA-E variations and disease severity parameters, providing biological clues for understanding the mechanisms associated with hepatitis C.

HUMAN IMMUNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Treatment failure with DAA therapy: Importance of resistance

Christoph Sarrazin

Summary: Viral resistance is a major factor in virological failure of patients with chronic HCV infection receiving DAAs treatment, with the importance varying based on DAA regimen and HCV genotype. First-line therapy with G/P or VEL/SOF may not require baseline resistance analysis, while VOX/VEL/SOF is the preferred second-line treatment option. Different patient subgroups may benefit from resistance testing to optimize therapy.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Microbiology

Extent of Cytomegalovirus Replication in the Human Host Depends on Variations of the HLA-E/UL40 Axis

Hannes Vietzen et al.

Summary: The study reveals the complex interaction between human cytomegalovirus (HCMV) and host immune responses, particularly the interaction between HLA-E and the virus-encoded UL40 peptide, leading to a potent NK cell response and reduction in virus replication in immunosuppressed patients. Different naturally occurring HCMV-UL40 variants reduce the activation of specific host NK cells subpopulation and are associated with high-level viremia in patients, highlighting the importance of understanding these interactions in the development of severe HCMV infection and vaccine strategies.

MBIO (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dimorphism of HLA-E and Its Disease Association

Leonid Kanevskiy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Immunology

Susceptibility of HLA-E*01:03 Allele Carriers to Develop Cytomegalovirus Replication After Living-Donor Kidney Transplantation

Hana Guberina et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Direct antiviral agents (DAAs) - A new age in the treatment of hepatitis C virus infection

Ulrich Spengler

PHARMACOLOGY & THERAPEUTICS (2018)

添加到收藏夹

Article Immunology

Identification of novel HIV-1-derived HLA-E-binding peptides

Zara Hannoun et al.

IMMUNOLOGY LETTERS (2018)

添加到收藏夹

Article Immunology

HLA-E Peptide Repertoire and Dimorphism-Centerpieces in the Adaptive NK Cell Puzzle?

Alexander Roelle et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Retreatment With Sofosbuvir Plus Grazoprevir/Elbasvir Plus Ribavirin of Patients With Hepatitis C Virus Genotype 1 or 4 Who Previously Failed an NS5A-or NS3-Containing Regimen: The ANRS HC34 REVENGE Study

Victor de Ledinghen et al.

CLINICAL INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Oncology

NK cell maturation to CD56dim subset associated with high levels of NCRs overrides the inhibitory effect of NKG2A and recovers impaired NK cell cytolytic potential after allogeneic hematopoietic stem cell transplantation

Mehran Ghasemzadeh et al.

LEUKEMIA RESEARCH (2016)

添加到收藏夹

Review Hematology

Do human leukocyte antigen E polymorphisms influence graft-versus-leukemia after allogeneic hematopoietic stem cell transplantation?

Ehteramolsadat Hosseini et al.

EXPERIMENTAL HEMATOLOGY (2015)

添加到收藏夹

Article Immunology

HLA-E variants are associated with sustained virological response in HIV/hepatitis C virus-coinfected patients on hepatitis C virus therapy

Maria Guzman-Fulgencio et al.

AIDS (2013)

添加到收藏夹

Article Immunology

HLA-E polymorphisms in an Afro-descendant Southern Brazilian population

Luana Carvalho dos Santos et al.

HUMAN IMMUNOLOGY (2013)

添加到收藏夹

Article Oncology

The impact of HLA-E polymorphisms on relapse following allogeneic hematopoietic stem cell transplantation

Ehteramolsadat Hosseini et al.

LEUKEMIA RESEARCH (2013)

添加到收藏夹

Review Immunology

Clinical Significance of the HLA-E and CD94/NKG2 Interaction

Milena Iwaszko et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2011)

添加到收藏夹

Article Immunology

CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease

Min Fang et al.

IMMUNITY (2011)

添加到收藏夹

Article Immunology

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection

Enrico Brunetta et al.

AIDS (2010)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The Emerging Role of HLA-E-Restricted CD8(+) T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors

Gabriella Pietra et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

添加到收藏夹

Article Gastroenterology & Hepatology

Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses

Sandy Pelletier et al.

JOURNAL OF HEPATOLOGY (2010)

添加到收藏夹

Article Rheumatology

HLA-E Gene Polymorphism Associated With Susceptibility to Kawasaki Disease and Formation of Coronary Artery Aneurysms

Y. -J. Lin et al.

ARTHRITIS AND RHEUMATISM (2009)

添加到收藏夹

Article Immunology

The HLA-ER/HLA-ER Genotype Affects the Natural Course of Hepatitis C Virus (HCV) Infection and Is Associated with HLA-E-Restricted Recognition of an HCV-Derived Peptide by Interferon-γ-Secreting Human CD8+ T Cells

Daniela Schulte et al.

JOURNAL OF INFECTIOUS DISEASES (2009)

添加到收藏夹

Article Immunology

Clinical Significance of HLA-E*0103 Homozygosity on Survival After Allogeneic Hematopoietic Stem-Cell Transplantation

Martin Danzer et al.

TRANSPLANTATION (2009)

添加到收藏夹

Article Rheumatology

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia

Fabiana Paladini et al.

ARTHRITIS RESEARCH & THERAPY (2009)

添加到收藏夹

Review Cell Biology

The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity

L. C. Sullivan et al.

TISSUE ANTIGENS (2008)

添加到收藏夹

Article Immunology

Increased NKG2A found in cytotoxic natural killer subset in HIV-1 patients with advanced clinical status

Ruijun Zhang et al.

AIDS (2007)

添加到收藏夹

Article Cell Biology

HLA-E0101 and HLA-G010101 reduce the risk of Behcet's disease

K. S. Park et al.

TISSUE ANTIGENS (2007)

添加到收藏夹

Article Immunology

Homozygous status for HLA-E*0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation

Ryad Tamouza et al.

TRANSPLANTATION (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C

J Nattermann et al.

GUT (2006)

添加到收藏夹

Article Cell Biology

HLA-E and immunobiology of pregnancy

P Tripathi et al.

TISSUE ANTIGENS (2006)

添加到收藏夹

Review Immunology

MHC class IB molecules bridge innate and acquired immunity

JR Rodgers et al.

NATURE REVIEWS IMMUNOLOGY (2005)

添加到收藏夹

Article Hematology

The significance of transfusion in the past as a risk for current hepatitis B and hepatitis C infection: a study in endoscopy patients

HM Tawk et al.

TRANSFUSION (2005)

添加到收藏夹

Article Immunology

Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics

BK Kaiser et al.

JOURNAL OF IMMUNOLOGY (2005)

添加到收藏夹

Review Cell Biology

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis

A Ahmad et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2004)

添加到收藏夹

Article Cell Biology

Natural killer cells inhibit hepatitis C virus expression

Y Li et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2004)

添加到收藏夹

Article Cell Biology

HLA-E polymorphism in patients with nasopharyngeal carcinoma

N Hirankarn et al.

TISSUE ANTIGENS (2004)

添加到收藏夹

Article Multidisciplinary Sciences

HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes

G Pietra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

添加到收藏夹

Article Immunology

Natural killer cells and their receptors

D Middleton et al.

TRANSPLANT IMMUNOLOGY (2002)

添加到收藏夹

Article Immunology

Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein

S Crotta et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

添加到收藏夹

Article Immunology

Differential disappearance of inhibitory natural killer cell receptors during HAART and possible impairment of HIV-1-specific CD8 cytotoxic T lymphocytes

P Costa et al.

AIDS (2001)

添加到收藏夹

Article Immunology

Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion

T Kanai et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2001)

添加到收藏夹

Article Immunology

Cutting edge:: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis

M Ulbrecht et al.

JOURNAL OF IMMUNOLOGY (2000)

添加到收藏夹

Review Hematology

Benefits and complications of regular blood transfusion in patients with beta-thalassaemia major

D Prati

VOX SANGUINIS (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.