The orbitofrontal cortex represents advantageous choice in the Iowa gambling task

A good-based model, the central neurobiological model of economic decision-making, proposes that the orbitofrontal cortex (OFC) represents binary choice outcome, that is, the chosen good. A good is defined by a group of determinants characterizing the conditions in which the commodity is offered, including commodity type, cost, risk, time delay, and ambiguity. Previous studies have found that the OFC represents the binary choice outcome in decision-making tasks involving commodity type, cost, risk, and delay. Real-life decisions are often complex and involve uncertainty, rewards, and penalties; however, whether the OFC represents binary choice outcomes in a complex decision-making situation, for example, Iowa gambling task (IGT), remains unclear. Here, we propose that the OFC represents binary choice outcome, that is, advantageous choice versus disadvantageous choice, in the IGT. We propose two hypotheses: first, the activity pattern in the human OFC represents an advantageous choice; and second, choice induces an OFC-related functional network. Using functional magnetic resonance imaging and advanced machine-learning tools, we found that the OFC represented an advantageous choice in the IGT. The OFC representation of advantageous choice was related to decision-making performance. Choice modulated the functional connectivity between the OFC and the superior medial gyrus. In conclusion, the OFC represents an advantageous choice during the IGT. In the framework of a good-based model, the results extend the role of the OFC to complex decision-making situation when making a binary choice.

Automated summary

The central neurobiological model of economic decision-making suggests that the orbitofrontal cortex (OFC) represents the binary choice outcome, specifically the chosen good. In the Iowa gambling task (IGT), the OFC was found to represent advantageous choice. Decision-making performance and the functional connectivity between OFC and the superior medial gyrus were influenced by choice in this complex decision-making situation.