4.3 Article

Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study

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Summary: Acute kidney injury is common in critical illness, and renal replacement therapy is needed for severe cases. In the UK, conventional systemic heparin anticoagulation for continuous renal replacement therapy is being replaced by regional citrate anticoagulation, but the safety and long-term effectiveness of this shift is not well-established. The Renal Replacement Anticoagulant Management (RRAM) study aims to use existing data sources to evaluate the clinical and cost-effectiveness of regional citrate anticoagulation compared to systemic heparin anticoagulation in UK ICUs.

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