期刊
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 260, 期 9, 页码 2925-2932出版社
SPRINGER
DOI: 10.1007/s00417-022-05671-0
关键词
Autoantibodies; Autoimmune diseases; Dry eye disease; Sjogren's syndrome
资金
- Seoul National University Bundang Hospital (SNUBH) Research Fund [02-2018-045]
- National Research Foundation of Korea [NRF-2019R1G1A1009371]
- Ministry of Education, Science, and Technology, Seoul, Korea
This study aimed to investigate the impact of serum anti-La antibodies on clinical parameters of dry eye disease (DED) and evaluate the correlation between antibody titers and DED parameters. The results showed a significant correlation between anti-Ro titers and conjunctival staining score, while no statistical correlation was found between anti-La and clinical DED parameters. Additionally, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La.
Purpose To investigate the difference in clinical parameters of dry eye disease (DED) according to the presence of serum anti-La antibodies and evaluate the correlations of autoantibody titers with DED parameters in patients with primary Sjogren's syndrome (pSS). Methods Sixty-two patients diagnosed with pSS according to the 2016 ACR-EULAR classification criteria were classified into two groups depending on the presence of anti-La antibodies: group 1 (anti-Ro positive alone, n=31) and group 2 (both anti-Ro and anti-La positive, n=31). DED parameters (conjunctival and corneal ocular staining score (OSS), tear film break-up time (TBUT), Schirmer I test, lipid layer thickness (LLT), meiboscore, and ocular surface disease index), serum autoantibodies (anti-Ro, anti-La, rheumatoid factor (RF), and antinuclear antibody) and focus score were assessed. Results The DED parameters were not significantly different between the two groups (P> 0.05). The anti-Ro titers, RF-positive rate, and the focus score were significantly higher in group 2 than in group 1 (P = 0.001, P = 0.049, P = 0.001, respectively). The anti-Ro titers had a significant positive correlation with conjunctival OSS (r =0.273, P = 0.033) and the focus score had a positive correlation with LLT and meiboscore (r = - 0.358, P = 0.072; r = 0.379, P = 0.056). Conclusion In this study, anti-Ro titers significantly correlated with conjunctival staining score, whereas anti-La did not statistically correlated with clinical DED parameters in SS. Meanwhile, anti-Ro titers and focus score were significantly higher in patients positive for both anti-Ro and anti-La, which suggests that examining anti-La with anti-Ro would be helpful in predicting clinical severities of SS patients.
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