KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1

Article Biochemistry & Molecular Biology

Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages

Hyunju Kang et al.

Summary: The study demonstrates that astaxanthin has anti-inflammatory and antioxidant properties in ethanol-treated macrophages by modulating the opposite effects of SIRT1 and HDAC4.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Macrophages, Metabolites, and Nucleosomes: Chromatin at the Intersection between Aging and Inflammation

Michael C. Church et al.

Summary: Inflammation serves as the body's defense mechanism against harmful stimuli, aiming to restore homeostasis. While controlled acute inflammation can transiently activate the immune response beneficially, dysregulated inflammatory responses, such as chronic inflammation, disrupt immune system balance, leading to increased susceptibility to infection, ongoing tissue damage, and dysfunction. Aging is a risk factor for chronic inflammation, and chromatin structure changes are associated with aging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

MicroRNA-200b-3p promotes endothelial cell apoptosis by targeting HDAC4 in atherosclerosis

Fan Zhang et al.

Summary: The study found 250 differentially expressed miRNAs in EAT from CAD patients, mainly related to metabolism, extracellular matrix, and inflammation processes. The expression levels of miR-200 family members, rich in endothelial cells, were significantly increased in EAT from CAD patients. Overexpression of miR-200b-3p targeting HDAC4 inhibition could promote endothelial cell apoptosis under oxidative stress.

BMC CARDIOVASCULAR DISORDERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

MicroRNA-301a-3p increases oxidative stress, inflammation and apoptosis in ox-LDL-induced HUVECs by targeting KLF7

Huiqiong Jiang et al.

Summary: This study identified that miR-301a-3p promotes oxidative stress, inflammation, and apoptosis in ox-LDL-induced HUVECs by inhibiting KLF7 expression.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

Wendi Wei et al.

Summary: The study revealed that HDAC4 plays a key role in regulating airway inflammation and remodeling in asthma through the KLF5/Slug/CXCL12 axis, suggesting it may be a potential target for asthma treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression

Alessandro Venosa et al.

Summary: Activated macrophages are associated with histone modifications and altered miRNA expression in lung injury and fibrosis induced by nitrogen mustard. The DNA damage response in macrophages included methylation and acetylation of histones, while changes in miRNA expression profiles were observed at different time points post-exposure. The data suggest that nitrogen mustard promotes histone remodeling and alterations in miRNA expression, impacting macrophage responses in lung injury and fibrosis.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology