期刊
GERIATRICS
卷 7, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/geriatrics7020024
关键词
Alzheimer's disease; natural products; oxidative stress; herbal medicine; antioxidant; amyloid beta; tau protein; anti-inflammatory
This article examines the neuroprotective effects of herbal plant extracts as alternative interventions for the progression of Alzheimer's disease. These extracts contain key metabolites that can alter the progression of the disease and have beneficial properties such as antioxidants, anti-inflammatory effects, and enhanced cognition.
Alzheimer's disease (AD) is an age-related, progressive neurodegenerative disorder characterized by impaired cognition, memory loss, and altered personality. Many of the available pharmaceutical treatments do not alter the onset of disease progression. Recently, alternatives to developed drug candidates have been explored including medicinal plants and herbal treatments for the treatment of AD. This article examines the role of herbal plant extracts and the neuroprotective effects as alternative modes of intervention for AD progression. These extracts contain key metabolites that culminate alterations in AD progression. The traditional plant extracts explored in this article induce a variety of beneficial properties, including antioxidants, anti-inflammatory, and enhanced cognition, while also inducing activity on AD drug targets such as A beta degradation. While these neuroprotective aspects for AD are relatively recent, there is great potential in the drug discovery aspect of these plant extracts for future use in AD treatment.
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