期刊
GENES & DEVELOPMENT
卷 36, 期 7-8, 页码 391-407出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.349358.122
关键词
intermediate filaments; vimentin; vimentin-null mouse
资金
- National Institutes of Health (NIH)-National Institute of General Medical Sciences (NIGMS) [GM096971]
- NIH-National Heart, Lung, and Blood Institute [HL154998, HL128194]
- NIH-National Institute on Aging [AG049665]
- Academy of Finland
- Sigrid Juselius Foundation
- Magnus Ehrnrooth Foundation
- Endowment of the Abo Akademi University
- Foundation Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Swedish Medical Research Council [2017-02255]
- ALF Gothenburg [146051]
- AFA (Arbetsmarknadens Forsakringsaktiebolag) Research Foundation
- Soderbergs Foundations
- Sten A. Olsson Foundation for Research and Culture
- Hjarnfonden
- Hagstromer's Foundation Millennium
- Amlov's Foundation
- E. Jacobson's Donation Fund
- VINNOVA (Sweden's Innovation Agency)
- Swedish Stroke Foundation
- La Caixa Foundation
- EU FP 7 Program EduGlia [237956]
- EU FP 7 Program TargetBraIn [279017]
- EU Horizon Europe European Joint Programme on Rare Diseases ALEXANDER (The astrocyte nanofilament system in Alexander disease-from molecules to function, uncovering new leads for therapy)
- COST Action NanoNet [BM1002]
- COST Action EuroCellNet [CA15214]
- NIH-NIGMS [GM096971, GM140108]
- Swedish Research Council [2017-02255] Funding Source: Swedish Research Council
This review discusses the essential functions of vimentin intermediate filaments (IFs) revealed from studies of Vim(-/-) mice and cells derived from them. It has been found that Vim(-/-) mice and their organs, tissues, and cells exhibit various phenotypes, frequently reflecting altered responses in tissue recovery. Cell-based experiments have confirmed the critical role of vimentin IFs in regulating cell mechanics.
In this review, Ridge et al. discuss the essential functions of vimentin IFs revealed from studies of Vim(-/-) mice and cells derived from them. More than 27 yr ago, the vimentin knockout (Vim(-/-)) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim(-/-) mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim(-/-) mice and cells derived from them.
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