期刊
GENE
卷 819, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.gene.2022.146242
关键词
Regeneration; Heart; Regulation; Transcription factors; Danio rerio
资金
- Fundac ~ao de Amparo `a pesquisa do Estado do Rio Grande do Sul (FAPERGS-FAPESP) [19/2551-0000953-3]
- Fundac ~ao de Amparo `a Pesquisa do Estado de S ~ao Paulo (FAPESP) [2018/05484-0]
- Coordenac ~ao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
- AUXPE [2537/2018]
- Coordenac ~ao de Aperfeicoamento de Pessoal de Nivel Superior
- Conselho Nacional de Desenvolvimento Cientifico e Tecnol 'ogico
In this study, we identified 135 transcription factors driving the cellular state transition process during zebrafish cardiac regeneration using a systematic review and in silico analysis. We found that most of these regulators are activated in the first few days post-injury, indicating a prompt transition from a non-regenerative to a regenerative state.
The limited regenerative capacity in mammals has serious implications for cardiac tissue damage. Meanwhile, zebrafish has a high regenerative capacity, but the regulation of the heart healing process has yet to be eluci-dated. The dynamic nature of cardiac regeneration requires consideration of the inherent temporal dimension of this process. Here, we conducted a systematic review to find genes that define the regenerative cell state of the zebrafish heart. We then performed an in silico temporal gene regulatory network analysis using transcriptomic data from the zebrafish heart regenerative process obtained from databases. In this analysis, the genes found in the systematic review were used to represent the final cell state of the transition process from a non-regenerative cell state to a regenerative state. We found 135 transcription factors driving the cellular state transition process during zebrafish cardiac regeneration, including Hand2, Nkx2.5, Tbx20, Fosl1, Fosb, Junb, Vdr, Wt1, and Tcf21 previously reported for playing a key role in tissue regeneration. Furthermore, we demonstrate that most reg-ulators are activated in the first days post-injury, indicating that the transition from a non-regenerative to a regenerative state occurs promptly.
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