期刊
GENE
卷 820, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.gene.2022.146257
关键词
FOS; Hair follicle development; RNA-seq; H; E staining; Differential expression
资金
- Ningxia Agricultural Breeding Program [2013NYYZ0402]
This study reveals significant gene expression differences between the birth and Er-mao periods in Chinese Tan sheep, with FOS gene being the most significantly differentially expressed gene. The FOS gene is significantly enriched in the signaling pathway related to hair follicle development.
Hair follicle development in Tan sheep differs significantly between the birth and Er-mao periods, but the underlying molecular mechanism is still unclear. We profiled the skin transcriptomes of Tan sheep in the birth and Er-mao periods via RNA-seq technology. The Tan sheep examined consisted of three sheep in the birth period and three sheep in the Er-mao period. A total of 364 differentially expressed genes (DEGs) in the skin of Tan sheep between the birth period and the Er-mao period were identified, among which 168 were upregulated and 196 were downregulated. Interestingly, the FOS proto-oncogene (FOS) (fold change = 22.67, P value = 2.15*10(boolean AND)44) was the most significantly differentially expressed gene. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found that the FOS gene was significantly enriched in the signaling pathway related to hair follicle development. Immunohistochemical analysis showed that the FOS gene was expressed in the skin of Chinese Tan sheep at the birth and Er-mao periods, with significantly higher expression in the Er-mao period. Our findings suggest that the FOS gene promotes hair follicle development in Tan sheep.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据