4.4 Article

Methylation site APC112043544 as a potential biomarker for post-transplant hepatocellular carcinoma recurrence

期刊

FUTURE ONCOLOGY
卷 18, 期 19, 页码 2401-2413

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FUTURE MEDICINE LTD
DOI: 10.2217/fon-2021-1608

关键词

APC gene; DNA methylation; hepatocellular carcinoma; liver transplantation; tumor recurrence

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资金

  1. Jinan Provincial Laboratory Research Project of Microecological Biomedicine
  2. Medicine and Health Science and Technology Plan Projects of Zhejiang Province [2022KY245]
  3. Science and Technology program of Jinhua Science and Technology Bureau [2021-4-178]

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This study found that the APC112043544 methylation site is an independent predictor for HCC recurrence after liver transplantation and may serve as a potential biomarker.
Objective: To investigate the prognostic value of DNA methylation of tumor suppressor genes for hepatocellular carcinoma (HCC) recurrence after liver transplantation. Methods: APC gene was selected according to The Cancer Genome Atlas dataset. Tumor tissues and clinical data of 85 HCC patients who received a liver transplantation were retrospectively enrolled and next-generation methylation sequencing was performed. Risk factors were determined using the Cox proportional-hazard-regression model. Results: The APC methylation site (chromosome 5, position 112043544) was an independent predictor of post-transplant HCC recurrence. Patients with hyper-methylated APC112043544 experienced superior recurrence-free survival (p = 0.021) and had a decreased proportion of microvascular invasion (p = 0.017). APC112043544 also predicted recurrence risk in patients beyond selection criteria. Conclusions: APC112043544 methylation may serve as a potential biomarker for post-transplant HCC recurrence.

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