4.5 Review

Antibacterial pyrazoles: tackling resistant bacteria

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Antibacterial evaluation and molecular docking studies of pyrazole-thiosemicarbazones and their pyrazole-thiazolidinone conjugates

Oluwakemi Ebenezer et al.

Summary: A library of pyrazole-thiazolidinone conjugates was synthesized using a Vilsmeier-Haack reaction, and tested for antimicrobial activity against various Gram-positive and Gram-negative bacteria. Compounds 3a and 4b emerged as the most potent antimicrobial compounds with minimum bactericidal concentrations of < 0.2 µM. Molecular docking studies suggested these compounds interacted with their targets through hydrogen bonding.

MOLECULAR DIVERSITY (2021)

Article Chemistry, Physical

Facile synthesis, antimicrobial evaluation and molecular docking studies of pyrazole-imidazole-triazole hybrids

Suman Punia et al.

Summary: A series of pyrazole-imidazole-triazole hybrids were synthesized and evaluated for antimicrobial activity, with one compound demonstrating excellent potency against A. niger. Molecular docking studies were used to determine the binding conformation of the most active compounds.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Editorial Material Biochemistry & Molecular Biology

Carbapenem and Colistin Resistance in Enterobacter: Determinants and Clones

Zhiyong Zong et al.

Summary: Enterobacter is a globally important pathogen with resistance to carbapenem and colistin. Further research is needed to understand colistin heteroresistance and the emergence of certain Enterobacter lineages clinically.

TRENDS IN MICROBIOLOGY (2021)

Review Immunology

Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniae Pathogenesis

Shekina Gonzalez-Ferrer et al.

Summary: Klebsiella pneumoniae, as Gram-negative facultative anaerobes, can cause a wide range of infections with different pathotypes, classical and hypervirulent strains. These distinct groups interact differently with the host immune system, and bacterial genetic diversity impacts the outcomes of these interactions. Understanding how K. pneumoniae interacts with mammalian innate immune host defenses highlights the importance of bacterial evolution and diversity in infection outcomes.

INFECTION AND IMMUNITY (2021)

Review Medicine, General & Internal

An Update on Eight New Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

Erlangga Yusuf et al.

Summary: Infections in the ICU are often caused by Gram-negative bacteria, which can become resistant to traditional antibiotics, limiting treatment options. In recent years, FDA has approved new antibiotics with predominant activities against Gram-negative bacteria, providing more choices for treatment in specific circumstances.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Chemistry, Medicinal

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

Bhautikkumar Patel et al.

Summary: This study synthesized 23 novel pyrazole linked phenylthiazole compounds and found that compound 14b exhibited promising antibacterial activity against MRSA with low toxicity. The results suggest that pyrazole linked phenylthiazole compounds have the potential to serve as lead compounds for the development of novel antibacterial agents.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Chemistry, Applied

Pyrazole-pyridinium porphyrins and chlorins as powerful photosensitizers for photoinactivation of planktonic and biofilm forms of E. coli

Isabela Santos et al.

Summary: The newly synthesized cationic porphyrins and chlorins demonstrate high efficiency in antimicrobial photodynamic therapy against both planktonic and biofilm forms of E. coli.

DYES AND PIGMENTS (2021)

Article Chemistry, Medicinal

4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents

Raj K. C. Hansa et al.

Summary: A collection of potent antimicrobials has been synthesized and tested for antibacterial activity, showing low toxicity to human cells. Two compounds were highly effective against Staphylococcus aureus, with a low tendency for resistance development. In vivo mouse studies showed no harmful effects at doses up to 50 mg/kg.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria

Ibrahim S. Alkhaibari et al.

Summary: This study reports the design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives, most of which are potent growth inhibitors of planktonic Gram-positive bacteria. Several lead compounds were identified to be bactericidal and effective against MRSA persisters, as well as S. aureus biofilms.

MOLECULES (2021)

Article Multidisciplinary Sciences

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance

Konstantin Shatalin et al.

Summary: The emergence of resistance to clinical antibiotics has prompted the development of a new antimicrobial strategy targeting the bacterial hydrogen sulfide (H2S) defense system. Inhibitors of the bacterial cystathionine g-lyase (CSE) have been found to enhance the effectiveness of bactericidal antibiotics against major human pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. These inhibitors also disrupt bacterial tolerance, reduce biofilm formation, and decrease the number of persister bacteria surviving antibiotic treatment.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

Design, synthesis, and antibacterial activity of N-(trifluoromethyl)phenyl substituted pyrazole derivatives

Ibrahim Saleh et al.

Summary: The study describes the design and synthesis of novel N-(trifluoromethyl)phenyl substituted pyrazole derivatives, which showed potent activity against antibiotic-resistant bacteria and biofilm formation. These compounds exhibited low toxicity and high selectivity towards human kidney cells, with potential as antimicrobial agents. Investigation into their mode of action revealed a broad inhibitory effect on bacterial cell function, making them promising candidates for further development as antibiotics.

RSC MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

New library of pyrazole-imidazo[1,2-α]pyridine molecular conjugates: Synthesis, antibacterial activity and molecular docking studies

Oluwakemi Ebenezer et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

Article Chemistry, Medicinal

β-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs

Concepcion Gonzalez-Bello et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

Zeinab Breijyeh et al.

MOLECULES (2020)

Review Microbiology

Combatting Persister Cells With Substituted Indoles

Sooyeon Song et al.

FRONTIERS IN MICROBIOLOGY (2020)

Editorial Material Infectious Diseases

Real-world antibiotic needs for resistant Gram-negative infections

Margaret A. Fitzpatrick

LANCET INFECTIOUS DISEASES (2020)

News Item Biotechnology & Applied Microbiology

Pharmaceutical firms commit US$1 billion to antibiotic development

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Biochemistry & Molecular Biology

Fraxinellone: From pesticidal control to cancer treatment

Christian Bailly et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

Article Chemistry, Medicinal

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

Silvia Stotani et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents

Tian-Yi Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Biotechnology & Applied Microbiology

2-Pyrazol-1-yl-thiazole derivatives as novel highly potent antibacterials

Yan A. Ivanenkov et al.

JOURNAL OF ANTIBIOTICS (2019)

Article Biochemistry & Molecular Biology

A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision

Justin E. Silpe et al.

Review Medicine, Research & Experimental

DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents

Tabassum Khan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Chemistry, Inorganic & Nuclear

Upconversion in photodynamic therapy: plumbing the depths

Michael R. Hamblin

DALTON TRANSACTIONS (2018)

Article Chemistry, Medicinal

Quinoline derivatives bearing pyrazole moiety: Synthesis and biological evaluation as possible antibacterial and antifungal agents

Mohamed F. El Shehry et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Synthesis and evaluation of thiazolidinone-pyrazole conjugates as anticancer and antimicrobial agents

Mahima Bhat et al.

FUTURE MEDICINAL CHEMISTRY (2018)

Editorial Material Biotechnology & Applied Microbiology

Disrupting MRSA 'persisters'

Conor A. Bradley

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Public, Environmental & Occupational Health

A rare and emerging pathogen: Raoultella planticola identification based on 16S rRNA in an infant

Serkan Atici et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2018)

Review Microbiology

Past and Present Perspectives on β-Lactamases

Karen Bush

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Article Chemistry, Organic

Synthesis and antibacterial evaluation of fused pyrazoles and Schiff bases

Ashraf S. Hassan et al.

SYNTHETIC COMMUNICATIONS (2018)

Article Chemistry, Medicinal

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors

Claire E. Weston et al.

ACS INFECTIOUS DISEASES (2017)

Article Chemistry, Medicinal

Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity

Mija Ahn et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

News Item Multidisciplinary Sciences

Drug-resistant bacteria ranked

Cassandra Willyard

NATURE (2017)

Article Biochemistry & Molecular Biology

Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents

Cherupally Dayakar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

Article Engineering, Manufacturing

Novel polyacrylamide hydrogels by highly conductive, water-processable graphene

Ashraful Alam et al.

COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING (2017)

Article Biochemistry & Molecular Biology

A Gestalt approach to Gram-negative entry

Lynn L. Silver

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation

Long-Wang Chen et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2016)

Review Chemistry, Medicinal

The therapeutic voyage of pyrazole and its analogs: A review

Mohemmed Faraz Khan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

Nestor Concha et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Mechanisms of resistance to membrane-disrupting antibiotics in Gram-positive and Gram-negative bacteria

Kfir B. Steinbuch et al.

MEDCHEMCOMM (2016)

Review Biotechnology & Applied Microbiology

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

Sirijan Santajit et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Chemistry, Medicinal

A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase

Tomasz L. Czarny et al.

ACS INFECTIOUS DISEASES (2016)

Review Pharmacology & Pharmacy

Current status of pyrazole and its biological activities

Mohd Javed Naim et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2016)

Article Chemistry, Medicinal

New INH-pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity

Nagabhushana Nayak et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Chemistry, Medicinal

The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

Li-Gang Yu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Biotechnology & Applied Microbiology

ESKAPEing the labyrinth of antibacterial discovery

Ruben Tommasi et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Chemistry, Medicinal

Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics

Xi-Le Hu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Article Infectious Diseases

Prevalence and resistance pattern of Moraxella catarrhalis in community-acquired lower respiratory tract infections

Safia Bader Uddin Shaikh et al.

INFECTION AND DRUG RESISTANCE (2015)

Review Microbiology

Bacterial gasotransmitters: an innate defense against antibiotics

Lyly Luhachack et al.

CURRENT OPINION IN MICROBIOLOGY (2014)

Article Chemistry, Medicinal

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

John I. Manchester et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Immunology

Cellular aspects of immunity to intracellular Salmonella enterica

Jonathan Jantsch et al.

IMMUNOLOGICAL REVIEWS (2011)

Article Biochemical Research Methods

The FGGY Carbohydrate Kinase Family: Insights into the Evolution of Functional Specificities

Ying Zhang et al.

PLOS COMPUTATIONAL BIOLOGY (2011)

Review Microbiology

A brief history of the antibiotic era: lessons learned and challenges for the future

Rustam I. Aminov

FRONTIERS IN MICROBIOLOGY (2010)

Article Immunology

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

Helen W. Boucher et al.

CLINICAL INFECTIOUS DISEASES (2009)

Editorial Material Medicine, General & Internal

The introduction of 'chemotherapy' using arsphenamine - the first magic bullet

K. J. Williams

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2009)

Article Biochemistry & Molecular Biology

Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure

Kenji Murano et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

Article Economics

Cost-utility analysis of rimonabant in the treatment of obesity

Christian Hampp et al.

VALUE IN HEALTH (2008)

Article Biochemistry & Molecular Biology

An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus

Peng R. Chen et al.

NATURE CHEMICAL BIOLOGY (2006)

Article Medicine, General & Internal

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

G Steinbach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)