期刊
FUTURE MEDICINAL CHEMISTRY
卷 14, 期 5, 页码 343-362出版社
Newlands Press Ltd
DOI: 10.4155/fmc-2021-0275
关键词
Acinetobacter baumannii; antibacterial; antibiotics; antimicrobials; bacterial resistance; drug-resistant; ESKAPE pathogens; MRSA; pyrazole
资金
- National Institute of General Medical Sciences (NIGMS) from the National Institutes of Health [P20 GM103429]
Bacterial resistance to antibiotics is a major threat to healthcare, modern medicine, food production, and life expectancy. Recent studies have shown that pyrazole derivatives, known for their wide range of pharmacological properties, can target different bacterial strains, including drug-resistant variants.
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.
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