期刊
FRONTIERS IN HUMAN NEUROSCIENCE
卷 16, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2022.832170
关键词
Fahr's disease; bilateral striopallidodentate calcinosis; balance; center of mass; posturography; gait analysis; rehabilitation
资金
- Italian Ministry of Health within the RESET research project (Istituto Auxologico Italiano, IRCCS, Ricerca Corrente)
This study analyzed the balance ability of patients with Fahr's disease and found vestibular balance control impairment during standing. The characteristics of balance impairment outlined in this study are of great significance for neurologists and physiatrists in detecting, staging, and treating this rare condition.
Fahr's disease is a rare idiopathic degenerative disease characterized by calcifications in the brain, and has also been associated with balance impairment. However, a detailed analysis of balance in these patients has not been performed. A 69-year-old woman with Fahr's disease presented with a long-lasting subjective imbalance. Balance was analyzed using both clinical (EquiScale, Timed Up and Go test, and Dizziness Handicap Inventory-short form) and instrumented tests (the sway of the body center of mass during quiet, perturbed, and self-perturbed stance, and the peak curvature of the center of mass during single stance while walking on a force-treadmill). The patient's balance was normal during clinical tests and walking. However, during standing, a striking impairment in vestibular control of balance emerged. The balance behavior displayed mixed parkinsonian (e.g., slowness and reduced amplitude of movement) and cerebellar (e.g., increased sway during standing in all conditions and decomposition of movement) features, with a discrepancy between the high severity of the static and the low severity of the dynamic balance impairment. The balance impairment characteristics outlined in this study could help neurologists and physiatrists detect, stage, and treat this rare condition.
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