4.7 Article

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Hong Sun et al.

Summary: This study provides global, regional, and country-level estimates of diabetes prevalence and health expenditures for 2021 and projections for 2045. The global prevalence of diabetes is increasing and is expected to have the greatest relative increase in middle-income countries. Diabetes-related health expenditures are also projected to rise.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

Article Neurosciences

Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice

Jasvinder Singh Bhatti et al.

Summary: The study found that SS31 treatment in diabetic mice could reduce mitochondrial dysfunction, restore mitochondrial function, lower lipid peroxidation, and increase ATP production, serving as a potential protective measure.

MOLECULAR NEUROBIOLOGY (2021)

Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, treatment goals, guidelines, and tools for evaluating care quality. It is updated annually by a multidisciplinary expert committee, and readers are invited to comment on the standards at professional.diabetes.org/SOC.

DIABETES CARE (2021)

Review Chemistry, Medicinal

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Aurelia Magdalena Pisoschi et al.

Summary: This review paper examines the chemistry of oxidative stress mitigation by antioxidants, highlighting the crucial role of balancing pro-oxidant and antioxidant species. It discusses the association between oxidative stress and various diseases, elucidating the types, mechanisms, and defense strategies of antioxidants.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Environmental Sciences

High levels of organochlorine pesticides in drinking water as a risk factor for type 2 diabetes: A study in north India

Shipra Tyagi et al.

Summary: Organochlorine pesticides (OCPs) are synthetic pesticides widely used in agriculture and public health, posing challenges due to their high toxicity, slow degradation, and bioaccumulation. This study in North India found higher OCP levels in groundwater than tap water, with a positive association between OCP levels and risk of developing type 2 diabetes mellitus (T2DM) after long-term exposure to contaminated groundwater. The findings highlight the importance of monitoring OCP contamination in drinking water to mitigate health risks, particularly related to diabetes.

ENVIRONMENTAL POLLUTION (2021)

Review Biochemistry & Molecular Biology

The Pancreatic β-Cell: The Perfect Redox System

Petr Jezek et al.

Summary: Pancreatic beta-cell insulin secretion is regulated by NADPH oxidase 4-mediated H2O2 production, requiring both ATP and H2O2 elevation to close the K-ATP channel. Additionally, simultaneous activation of other channels is necessary for the pulsatile exocytosis of insulin granule vesicles.

ANTIOXIDANTS (2021)

Article Multidisciplinary Sciences

Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus

Guoxiu Zu et al.

Summary: In this study, potential molecular targets of quercetin were identified using bioinformatics methods, and the therapeutic potential of quercetin in type 2 diabetes mellitus and Alzheimer's disease was explored. The study provides insights into potential therapeutic targets and pathways for further clinical research.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Targeting Mitochondria in Diabetes

Nina Krako Jakovljevic et al.

Summary: This review examines mitochondrial function in liver, muscle, and blood cells in the context of T2D, focusing on human studies. Results suggest that mitochondrial respiratory capacity could serve as a metabolic indicator, decreasing as the disease progresses but increasing after lifestyle and pharmacological interventions, leading to improved metabolic health. Novel therapeutics targeting mitochondria show potential for a more comprehensive approach in treating diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Endocrinology & Metabolism

The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study

Milena Cojic et al.

Summary: The study suggests that daily oral doses of vitamin D can improve HbA1c levels over a period of 3 and 6 months, with a significant decrease in advanced oxidation protein products levels after 3 months of higher vitamin D doses. However, the impact of vitamin D on the HOMA-IR index, malondialdehyde levels, and TG/TBARS index was not statistically significant. Further research should focus on determining the appropriate doses of vitamin D in patients with type 2 diabetes to mitigate oxidative stress risk, metabolic syndrome risk, and related cardiovascular events.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Physiology

Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study

Chongchira Boonthongkaew et al.

Summary: The study showed that 6-week Vitamin C supplementation could reduce pre-exercise and post-exercise blood pressure, possibly through improved oxidative stress and NO release. However, exercise did not have any effect on the outcome measures.

CHINESE JOURNAL OF PHYSIOLOGY (2021)

Review Pharmacology & Pharmacy

Macrovascular Complications of Type 2 Diabetes Mellitus

Margus Viigimaa et al.

CURRENT VASCULAR PHARMACOLOGY (2020)

Review Clinical Neurology

Challenges of neuropathic pain: focus on diabetic neuropathy

Daniela C. Rosenberger et al.

JOURNAL OF NEURAL TRANSMISSION (2020)

Review Endocrinology & Metabolism

Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus

W. Riski Widya Mulyani et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Review Geriatrics & Gerontology

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Gurjit Kaur Bhatti et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

Beneficial effects of (-)-epigallocatechin-3-O-gallate on diabetic peripheral neuropathy in the rat model

Osama Mohamed Abo-Salem et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

Review Endocrinology & Metabolism

Molecular complexities underlying the vascular complications of diabetes mellitus - A comprehensive review

Shalini Paul et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2020)

Article Multidisciplinary Sciences

Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes

Akira Mima et al.

SCIENTIFIC REPORTS (2020)

Article Endocrinology & Metabolism

Effects of Hydroxysafflor Yellow A on the PI3K/AKT Pathway and Apoptosis of Pancreatic beta-Cells in Type 2 Diabetes Mellitus Rats

Maosheng Lee et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Review Biochemistry & Molecular Biology

Calorie Restriction and Aging in Humans

Emily W. Flanagan et al.

ANNUAL REVIEW OF NUTRITION, VOL 40, 2020 (2020)

Article Biochemistry & Molecular Biology

Role of Nrf2 dysfunction in the pathogenesis of diabetic nephropathy: Therapeutic prospect of epigallocatechin-3-gallate

Thangarajeswari Mohan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Endocrinology & Metabolism

Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications

Eleftheria Papachristoforou et al.

JOURNAL OF DIABETES RESEARCH (2020)

Review Cardiac & Cardiovascular Systems

Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy

Nina Kaludercic et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Article Public, Environmental & Occupational Health

Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends

Moien Abdul Basith Khan et al.

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH (2020)

Review Biochemistry & Molecular Biology

Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review

Ester Casanova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cardiac & Cardiovascular Systems

Dietary patterns and management of type 2 diabetes: A systematic review of randomised clinical trials

D. Papamichou et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2019)

Review Biochemistry & Molecular Biology

Molecular and cellular bases of diabetes: Focus on type 2 diabetes mouse model-TallyHo

Kavya Tamarai et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Medicine, Research & Experimental

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Elizabeta Zaplatic et al.

LIFE SCIENCES (2019)

Article Medicine, General & Internal

Diabetic neuropathy

Eva L. Feldman et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Review Chemistry, Medicinal

Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018)

Hidayat Hussain et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2019)

Article Agriculture, Multidisciplinary

Gymnemic Acid Ameliorates Hyperglycemia through PI3K/AKT- and AMPK-Mediated Signaling Pathways in Type 2 Diabetes Mellitus Rats

Yumeng Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Review Nutrition & Dietetics

Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity

Veronica Lazar et al.

FRONTIERS IN NUTRITION (2019)

Review Endocrinology & Metabolism

The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)

Michael Halim et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Review Endocrinology & Metabolism

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Yan Zheng et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

Article Endocrinology & Metabolism

Association of serum vitamin D levels and diabetic retinopathy in Asian Indians with type 2 diabetes

Beteal Ashinne et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Public, Environmental & Occupational Health

A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus

Lukas Schwingshackl et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2018)

Review Pharmacology & Pharmacy

Targeting oxidative stress through antioxidants in diabetes mellitus

Parul Thakur et al.

JOURNAL OF DRUG TARGETING (2018)

Article Biochemistry & Molecular Biology

Non-musculoskeletal benefits of vitamin D

Sunil J. Wimalawansa

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Article Materials Science, Biomaterials

In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes

Richa Panwar et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Review Pharmacology & Pharmacy

Pharmacogenetics of oral antidiabetic therapy

Anna-Maria Ordelheide et al.

PHARMACOGENOMICS (2018)

Review Cell Biology

Cellular death, reactive oxygen species (ROS) and diabetic complications

Caroline Maria Oliveira Volpe et al.

CELL DEATH & DISEASE (2018)

Review Environmental Sciences

Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review

Tashi Dendup et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Biology

Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway

Song Fu et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Agriculture, Dairy & Animal Science

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Qingwei Meng et al.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2018)

Review Endocrinology & Metabolism

Type 2 diabetes in adolescents and young adults

Nadia Lascar et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

Redox imbalance stress in diabetes mellitus: Role of the polyol pathway

Liang-jun Yan

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2018)

Review Pharmacology & Pharmacy

Antioxidant effects of resveratrol in the cardiovascular system

Ning Xia et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Nutrition & Dietetics

Prevalence of type 2 diabetes and its complications in India and economic costs to the nation

R. Pradeepa et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2017)

Article Biochemistry & Molecular Biology

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

Weixia Sun et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy

Daiji Kawanami et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Medicine, General & Internal

Role of Vitamin D on glycemic control and oxidative stress in type 2 diabetes mellitus

Mostafa Saif-Elnasr et al.

JOURNAL OF RESEARCH IN MEDICAL SCIENCES (2017)

Review Medicine, General & Internal

Type 2 diabetes

Sudesna Chatterjee et al.

LANCET (2017)

Review Endocrinology & Metabolism

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Sonia Sifuentes-Franco et al.

JOURNAL OF DIABETES RESEARCH (2017)

Article Biology

Neuroprotective effects of quercetin in diabetic rat retina

Mohammad S. Ola et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2017)

Review Cell Biology

Calorie restriction in humans: An update

Jasper Most et al.

AGEING RESEARCH REVIEWS (2017)

Review Endocrinology & Metabolism

The mechanisms of action of metformin

Graham Rena et al.

DIABETOLOGIA (2017)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Jasvinder Singh Bhatti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Review Biochemistry & Molecular Biology

Molecular mechanisms of ROS production and oxidative stress in diabetes

Philip Newsholme et al.

BIOCHEMICAL JOURNAL (2016)

Article Medicine, General & Internal

Efficacy of lifestyle interventions in patients with type 2 diabetes: A systematic review and meta-analysis

Xiao-Li Huang et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2016)

Review Neurosciences

Calorie restriction as an intervention in ageing

Guillermo Lopez-Lluch et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Medicine, General & Internal

The association between Vitamin D and health outcomes in women: A review on the related evidence

Leila Azadbakht et al.

Journal of Research in Medical Sciences (2016)

Review Medicine, Research & Experimental

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

Vibha Rani et al.

LIFE SCIENCES (2016)

Article Biochemistry & Molecular Biology

Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways

Chunfang Ma et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)

Article Immunology

New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics

Rachna Patel et al.

CLINICAL INFECTIOUS DISEASES (2015)

Review Endocrinology & Metabolism

Linking RAGE and Nox in diabetic micro- and macrovascular complications

C. Koulis et al.

DIABETES & METABOLISM (2015)

Article Biochemistry & Molecular Biology

Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle

T. Li et al.

FREE RADICAL RESEARCH (2015)

Article Agriculture, Multidisciplinary

Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats

Yunfeng Gao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Article Cell Biology

Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK

Shuang Guo et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Article Urology & Nephrology

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

Katherine R. Tuttle et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2014)

Review Biochemistry & Molecular Biology

ROS Function in Redox Signaling and Oxidative Stress

Michael Schieber et al.

CURRENT BIOLOGY (2014)

Article Endocrinology & Metabolism

ESC Guidelines on diabetes, pre- diabetes, and cardiovascular diseases developed in collaboration with the EASD - Summary

Lars Ryden et al.

DIABETES & VASCULAR DISEASE RESEARCH (2014)

Article Ophthalmology

Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Binit Kumar et al.

EXPERIMENTAL EYE RESEARCH (2014)

Review Ophthalmology

Autophagy in the eye: Implications for ocular cell health

Laura S. Frost et al.

EXPERIMENTAL EYE RESEARCH (2014)

Review Biochemistry & Molecular Biology

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

Etsuo Niki

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Review Plant Sciences

REACTIVE OXYGEN SPECIES (ROS) GENERATION AND DETOXIFYING IN PLANTS

Armin Saed-Moucheshi et al.

JOURNAL OF PLANT NUTRITION (2014)

Article Biochemistry & Molecular Biology

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy

Isabele B. S. Gomes et al.

LIPIDS IN HEALTH AND DISEASE (2014)

Review Nutrition & Dietetics

Pharmacological potential of tocotrienols: a review

Haseeb Ahsan et al.

NUTRITION & METABOLISM (2014)

Article Chemistry, Physical

Homolytic and heterolytic O-H bond cleavage in trans-resveratrol and some phenantrene analogs: A theoretical study

Ali Benayahoum et al.

COMPUTATIONAL AND THEORETICAL CHEMISTRY (2014)

Review Biotechnology & Applied Microbiology

Calorie Restriction in Mammals and Simple Model Organisms

Giusi Taormina et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biotechnology & Applied Microbiology

PTEN Mediates the Antioxidant Effect of Resveratrol at Nutritionally Relevant Concentrations

Marta Ingles et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biotechnology & Applied Microbiology

Molecular Mechanisms of Curcumin on Diabetes-Induced Endothelial Dysfunctions: Txnip, ICAM-1, and NOX2 Expressions

Natchaya Wongeakin et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Biochemistry & Molecular Biology

Redox Environment, Free Radical, and Oxidative DNA Damage

Sarah J. Storr et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Biochemistry & Molecular Biology

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

Muhammad Sajid Hamid Akash et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

Article Multidisciplinary Sciences

Dietary intervention impact on gut microbial gene richness

Aurelie Cotillard et al.

NATURE (2013)

Review Endocrinology & Metabolism

KATP channels and islet hormone secretion: new insights and controversies

Frances M. Ashcroft et al.

NATURE REVIEWS ENDOCRINOLOGY (2013)

Article Pharmacology & Pharmacy

Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats

Orsu Prabhakar

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2013)

Review Cell Biology

Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy

O. Lorenzo et al.

MEDIATORS OF INFLAMMATION (2013)

Article Multidisciplinary Sciences

Efficacy of Biodegradable Curcumin Nanoparticles in Delaying Cataract in Diabetic Rat Model

Charitra N. Grama et al.

PLOS ONE (2013)

Review Endocrinology & Metabolism

Glucose-stimulated insulin secretion: A newer perspective

Mitsuhisa Komatsu et al.

JOURNAL OF DIABETES INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

Biological markers of oxidative stress: Applications to cardiovascular research and practice

Edwin Ho et al.

REDOX BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes

V. Calabrese et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Review Pharmacology & Pharmacy

The use of animal models in diabetes research

Aileen J. F. King

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Endocrinology & Metabolism

Air Pollution and Type 2 Diabetes Mechanistic Insights

Sanjay Rajagopalan et al.

DIABETES (2012)

Article Endocrinology & Metabolism

Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

S. E. Hussey et al.

DIABETES OBESITY & METABOLISM (2012)

Article Endocrinology & Metabolism

Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy

Solomon Tesfaye et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2012)

Article Pharmacology & Pharmacy

Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC-MAPK signaling pathway

Vivian Soetikno et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Review Pharmacology & Pharmacy

Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9

Renu A. Kowluru et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)

Article Biochemistry & Molecular Biology

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice

John R. Mercer et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

Vasanthi R. Muthusamy et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Multidisciplinary Sciences

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower et al.

NATURE (2012)

Review Endocrinology & Metabolism

The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives

Lei Chen et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Review Chemistry, Medicinal

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

Sadagopan Magesh et al.

MEDICINAL RESEARCH REVIEWS (2012)

Article Nutrition & Dietetics

Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis

An Pan et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

Review Cell Biology

The emerging role of autophagy in the pathophysiology of diabetes mellitus

Claudio D. Gonzalez et al.

AUTOPHAGY (2011)

Article Biochemistry & Molecular Biology

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling

P. Palsamy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Biochemistry & Molecular Biology

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

Erik J. Henriksen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Biochemistry & Molecular Biology

Oxidative stress, insulin signaling, and diabetes

Justin L. Rains et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Endocrinology & Metabolism

Glucolipotoxicity in Pancreatic β-Cells

Ji-Won Kim et al.

DIABETES & METABOLISM JOURNAL (2011)

Article Cardiac & Cardiovascular Systems

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

Zoltan Ungvari et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Article Biochemistry & Molecular Biology

Prevention of diabetic nephropathy in Ins2+/-AkitaJ mice by the mitochondria-targeted therapy MitoQ

Balu K. Chacko et al.

BIOCHEMICAL JOURNAL (2010)

Article Pharmacology & Pharmacy

Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite

Joseph H. Holthoff et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Review Cardiac & Cardiovascular Systems

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

Pedro Geraldes et al.

CIRCULATION RESEARCH (2010)

Review Biochemistry & Molecular Biology

Oxidatively generated base damage to cellular DNA

Jean Cadet et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Food Science & Technology

Antioxidant properties of resveratrol: A structure-activity insight

Ilhami Gulcin

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2010)

Article Endocrinology & Metabolism

Targeting beta-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus

Jack L. Leahy et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

Review Geriatrics & Gerontology

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Robin K. Minor et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)

Review Medicine, Research & Experimental

Green tea polyphenol epigallocatechi3-gallate: Inflammation and arthritis

Rashmi Singh et al.

LIFE SCIENCES (2010)

Review Cell Biology

Multifaceted approach to resveratrol bioactivity Focus on antioxidant action, cell signaling and safety

Peter Kovacic et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)

Article Behavioral Sciences

Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: A controlled clinical pilot study

Mustafa Naziroglu et al.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2010)

Review Pharmacology & Pharmacy

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

Jingbo Pi et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)

Article Medical Laboratory Technology

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

Daniela Giustarini et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2009)

Review Pharmacology & Pharmacy

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

Patrice D. Cani et al.

CURRENT PHARMACEUTICAL DESIGN (2009)

Article Endocrinology & Metabolism

Effects and clinical potential of very-low-calorie diets (VLCDs) in type 2 diabetes

Scott Baker et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2009)

Article Biochemistry & Molecular Biology

Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK

Tara L. Archuleta et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Review Medicine, Research & Experimental

Oxidative stress and metabolic syndrome

Christian K. Roberts et al.

LIFE SCIENCES (2009)

Article Multidisciplinary Sciences

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Carles Canto et al.

NATURE (2009)

Article Multidisciplinary Sciences

Subcellular localization of Nox4 and regulation in diabetes

Karen Block et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Public, Environmental & Occupational Health

Lipoperoxidation and antioxidant capacity in patients with poorly controlled type 2 diabetes

M. Lodovici et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2009)

Article Endocrinology & Metabolism

Catalase Deficiency and Type 2 Diabetes

L. Goth

DIABETES CARE (2008)

Article Food Science & Technology

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

Hye-Kyung Na et al.

FOOD AND CHEMICAL TOXICOLOGY (2008)

Review Pharmacology & Pharmacy

Inflammation in the vascular bed: Importance of vitamin C

Rene Aguirre et al.

PHARMACOLOGY & THERAPEUTICS (2008)

Review Pharmacology & Pharmacy

Mitochondrial medicine: Pharmacological targeting of mitochondria in disease

J. S. Armstrong

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Biochemical Research Methods

Protein glutathionylation and oxidative stress

Toshimitsu Niwa

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2007)

Article Peripheral Vascular Disease

Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients

Yvonne Plantinga et al.

AMERICAN JOURNAL OF HYPERTENSION (2007)

Review Cardiac & Cardiovascular Systems

Differential effects of oral hypoglycemic agents on glucose control and cardiovascular risk

Gabriel I. Uwaifo et al.

AMERICAN JOURNAL OF CARDIOLOGY (2007)

Review Medicine, General & Internal

Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes

Richard E. Pratley et al.

CURRENT MEDICAL RESEARCH AND OPINION (2007)

Review Urology & Nephrology

AGE, RAGE, and ROS in diabetic nephropathy

Adeline L. Y. Ton et al.

SEMINARS IN NEPHROLOGY (2007)

Review Biochemistry & Molecular Biology

Free radicals and antioxidants in normal physiological functions and human disease

Marian Valko et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Pharmacology & Pharmacy

Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats

Noriko Yamabe et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Cardiac & Cardiovascular Systems

Advanced glycation end products - Sparking the development of diabetic vascular injury

Alison Goldin et al.

CIRCULATION (2006)

Article Nutrition & Dietetics

Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States

Bente L. Halvorsen et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2006)

Review Medicine, Research & Experimental

TAGE (toxic AGEs) theory in diabetic complications

Takashi Sato et al.

CURRENT MOLECULAR MEDICINE (2006)

Article Biochemistry & Molecular Biology

Curcumin activates defensive genes and protects neurons against oxidative stress

Giovanni Scapagnini et al.

ANTIOXIDANTS & REDOX SIGNALING (2006)

Review Cell Biology

Critical nodes in signalling pathways: insights into insulin action

CM Taniguchi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Review Endocrinology & Metabolism

Hexosamines, insulin resistance, and the complications of diabetes: current status

MG Buse

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Review Biochemistry & Molecular Biology

Proposed mechanisms for the induction of insulin resistance by oxidative stress

A Bloch-Damti et al.

ANTIOXIDANTS & REDOX SIGNALING (2005)

Article Ophthalmology

Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats

P Suryanarayana et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

Article Endocrinology & Metabolism

PKC-δ-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice:: role for NADPH oxidase

I Talior et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)

Article Pharmacology & Pharmacy

Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes

SI Rizvi et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2005)

Article Pharmacology & Pharmacy

Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats

M Anjaneyulu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2004)

Review Medicine, General & Internal

Drug therapy: Thiazolidinediones

H Yki-Jarvinen

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Cardiac & Cardiovascular Systems

Antioxidant vitamin supplements and cardiovascular disease

PM Kris-Etherton et al.

CIRCULATION (2004)

Article Developmental Biology

Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression:: Involvement in diabetic teratogenesis

M Horal et al.

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2004)

Article Endocrinology & Metabolism

Oxidative stress is associated with adiposity and insulin resistance in men

H Urakawa et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Review Pathology

The role of advanced glycation in the pathogenesis of diabetic retinopathy

AW Stitt

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2003)

Article Endocrinology & Metabolism

The metabolic syndrome:: Peroxisome proliferator-activated receptor γ and its therapeutic modulation

M Gurnell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Review Biochemistry & Molecular Biology

The role of oxidative stress in diabetic vascular and neural disease

MA Yorek

FREE RADICAL RESEARCH (2003)

Article Biochemistry & Molecular Biology

Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

E Balogun et al.

BIOCHEMICAL JOURNAL (2003)

Review Pharmacology & Pharmacy

PTP1B inhibitors as potential therapeutics in the treatment of Type 2 diabetes and obesity

ZY Zhang et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2003)

Review Pharmacology & Pharmacy

Metformin - New understandings, new uses

RS Hundal et al.

Article Biochemistry & Molecular Biology

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

H Kaneto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Protection of flavonoids against lipid peroxidation: The structure activity relationship revisited

CGM Heijnen et al.

FREE RADICAL RESEARCH (2002)

Article Endocrinology & Metabolism

Dietary fat and meat intake in relation to risk of type 2 diabetes in men

RM van Dam et al.

DIABETES CARE (2002)

Article Plant Sciences

Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats

N Arun et al.

PLANT FOODS FOR HUMAN NUTRITION (2002)

Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

Letter Medicine, General & Internal

Pharmacologic therapy for type 2 diabetes mellitus

RA DeFronzo

ANNALS OF INTERNAL MEDICINE (2000)

Review Biochemistry & Molecular Biology

Protein kinase C signaling and oxidative stress

R Gopalakrishna et al.

FREE RADICAL BIOLOGY AND MEDICINE (2000)

Review Biochemistry & Molecular Biology

Dual action of the active oxygen species during plant stress responses

J Dat et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2000)

Article Endocrinology & Metabolism

What is oxidative stress?

DJ Betteridge

METABOLISM-CLINICAL AND EXPERIMENTAL (2000)

Article Public, Environmental & Occupational Health

A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women

SM Liu et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2000)

Article Urology & Nephrology

Role of the hexosamine biosynthetic pathway in diabetic nephropathy

ED Schleicher et al.

KIDNEY INTERNATIONAL (2000)