期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 182, 期 -, 页码 206-218出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2022.02.021
关键词
Intermittent fasting; Brain aging; Neurodegeneration; Mitochondrial dysfunction
资金
- National Natural Science Foundation of China [81871118, 81803231]
- Central Government Guides Local Science and Technology Development Fund Projects [2021Szvup119]
- Innovative Talent Promotion Program-Technology Innovation Team [2019TD-006]
- Small and Medium-Sized Technology-Based Enterprise Innovation Capacity Improvement Project in Shandong Province [2021TSGC1280]
- Tang Cornell-China Scholars Program from Cornell University in the U.S.
- Alexander von Humboldt-Stiftung in Germany
This review focuses on the mechanisms by which intermittent fasting (IF) improves mitochondrial function in brain aging and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. IF activates adaptive cellular stress responses and signaling pathways, enhancing mitochondrial function by promoting energy metabolism and reducing oxidant production.
Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as an early feature of brain aging and neurodegeneration. Although IF has been shown to prevent brain aging and neurodegeneration, the mechanism is still unclear. This review focuses on the mechanisms by which IF improves mitochondrial function, which plays a central role in brain aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The cellular and molecular mechanisms of IF in brain aging and neurodegeneration involve activation of adaptive cellular stress responses and signaling-and transcriptional pathways, thereby enhancing mitochondrial function, by promoting energy metabolism and reducing oxidant production.
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