期刊
FOOD RESEARCH INTERNATIONAL
卷 156, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2022.111180
关键词
Sequential fermentation; Obesity; Lipid-lowering; Fatty liver; Inflammation; Gut microbiota
资金
- National Key R&D Program of China [2017YFD0400702]
Low-alcohol beverages are harmful to the liver, while dealcoholized apple juice fermented by specific strains of yeast and bacteria shows promise as a dietary intervention for hyperlipidemia and fatty liver. This study identifies the mechanisms of action and demonstrates the potential of this functional beverage in ameliorating metabolic disorders associated with hyperlipidemia and obesity.
Low-alcohol beverages damage the liver, whereas dealcoholized apple juice sequentially fermented by Saccharomyces cerevisiae and Lactobacillus plantarum is a promising dietary intervention for hyperlipidaemia as a functional non-alcoholic beverage that lowers lipid levels and regulates fatty liver. However, their mechanisms of action have not been identified. In this study, we found that low-alcohol cider exacerbated inflammation in mice on a high-fat diet, up-regulate fatty liver CYP2E1 gene, and inhibit the expression of MBOAT7 and TMC4. Apple juice traditionally fermented by S. cerevisiae and then dealcoholized, followed by sequential fermentation by L. plantarum, can improve obesity and fatty liver, reduce the production of liver cholesterol and fat accumulation, and promote the production of short-chain fatty acids. Our research demonstrates that the lipopolysaccharide/ lipopolysaccharide-binding protein/cluster of differentiation 14 protein/Toll-like receptor 4 protein signaling pathway affects the occurrence of obesity and inflammation in mice, and the expression of CYP7A1 inhibits the production of lipids. Further research reveals that L. plantarum sequentially fermented dealcoholized apple juice not only regulate and restore the intestinal flora, but also change the ratio of Firmicutes-to-Bacteroides, and decreased endotoxin-bearing Proteobacteria levels. Together, this functional product may be a potential dietary strategy to interfere with hyperlipidemia and obesity-related metabolic disorders.
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