期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 84, 期 -, 页码 222-239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2014.11.015
关键词
Tendon; Tendon repair; Growth Factors; Cell-based therapy; Mesenchymal stem cells; Embryonic stem cells; Tendon-derived cells; Natural biomaterials; Gene therapy
资金
- German Research Foundation [DFG DO1414/3-1, DO1414/1-1, PO 1718/1-1]
- AO Research Foundation [S-10-47D, S-07-18D]
- Bavarian Research Foundation [DOK-100/08]
- NIH from NIAMS [R01 AR052809]
Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly because these injuries often respond poorly to treatment and require prolonged rehabilitation. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts, and synthetic prostheses. To date, none of these alternatives has provided a successful long-term solution, and often the restored tendons do not recover their complete strength and functionality. Unfortunately, our understanding of tendon biology lags far behind that of other musculoskeletal tissues, thus impeding the development of new treatment options for tendon conditions. Hence, in this review, after introducing the clinical significance of tendon diseases and the present understanding of tendon biology, we describe and critically assess the current strategies for enhancing tendon repair by biological means. These consist mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage. A deeper understanding of how tendon tissue and cells operate, combined with practical applications of modern molecular and cellular tools could provide the long awaited breakthrough in designing effective tendon-specific therapeutics and overall improvement of tendon disease management (C) 2014 The Authors. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据