期刊
FOOD HYDROCOLLOIDS
卷 124, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2021.107246
关键词
Astaxanthin; Chitosan oligosaccharide/alginate; nanoparticles; Encapsulation; Stability; Bioaccessibility; Bioavailability
资金
- Chulalongkorn University [CU-GR_63_52_62_02]
- Chulalongkorn University
In this study, ATX-loaded chitosan oligosaccharide/alginate nanoparticles (ATX-COANPs) were successfully fabricated with optimized conditions. These nanoparticles exhibited good stability and sustained release characteristics under various conditions. Encapsulation within COANPs led to increased in vitro bioaccessibility, bioavailability, and antioxidant activity of ATX, suggesting potential applications in developing an effective oral delivery system for nutraceuticals or functional foods.
Astaxanthin (ATX), a hydrophobic xanthophyll family of carotenoids, has various advantageous biological activities. Its use as a bioactive compound in functional foods, nutraceuticals, and dietary supplements is currently limited by its extremely low water solubility, poor bioaccessibility, and low bioavailability. To overcome these limitations, ATX-loaded chitosan oligosaccharide/alginate nanoparticles (ATX-COANPs) were fabricated by oil -in-water emulsification followed by ionotropic gelation, and conditions were optimized using the response surface methodology. Characteristics of optimal ATX-COANPs in terms of particle size, zeta potential, encap-sulation efficiency, and loading capacity were 264 +/- 32 nm, -22.1 +/- 1.3 mV, 71.3 +/- 2.2%, and 6.9 +/- 1.6%, respectively. On transmission electron microscopy, ATX-COANPs have a spherical shape with a smooth surface and even size distribution. ATX-COANPs demonstrated good stability during storage and exposure to UV light, heat, acidic-alkaline, oxidation, and simulated gastrointestinal (GI) fluid conditions. In vitro release studies in simulated GI fluids demonstrated that ATX was released from ATX-COANPs in a sustained manner with Fickian diffusion mechanism. The in vitro bioaccessibility, bioavailability, and antioxidant activity of ATX were increased after encapsulating within COANPs. These findings suggest that ATX-COANPs have potential applications in developing an effective oral delivery system of ATX in nutraceuticals or functional foods.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据