期刊
FOOD CHEMISTRY
卷 374, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.131493
关键词
Bioaccessibility; Cellular accumulation; Digestion stability; Isoflavone conjugate; Permeability; Transwell system
资金
- Rural Development Administration Agenda Project, Republic of Korea [PJ01251204]
This study evaluated the antioxidant capacity, bioaccessibility, and bioavailability of 12 soy isoflavones (SIs). The results showed that SIs were stable under gastric digestion conditions but unstable under small intestinal digestion conditions for acetyl and malonyl conjugates. SI aglycones had higher permeability and cellular accumulation than their glucosides. A small amount of intact SI conjugates were found in the cell and in the basolateral side of each Transwell.
Soy isoflavones (SIs) show various health benefits, such as antioxidant and estrogenic effects. It is important to understand the bioaccessibility and bioavailability of SIs due to the close relation to their bioactivities. In this study, the antioxidant capacity, bioaccessibility, and bioavailability of 12 SIs were evaluated using radicalscavenging methods, simulations of human digestion, and Caco-2 cells in Transwell, respectively. All SIs were stable (91.1-99.2%) under gastric digestion conditions compared with the control (100%), whereas acetyl and malonyl conjugates were unstable (38.5% and 65.5%, respectively) under small intestinal digestion conditions. SI aglycones showed higher permeability (7-15 times) and cellular accumulation (8.8 times) than their glucosides. A small amount of SI conjugates was intact in the cell and in the basolateral side of each Transwell. These results suggest that SI conjugates, especially malonyl and acetyl forms, have incidental bioactivity after being metabolized to aglycones inside the cell.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据