期刊
FOOD CHEMISTRY
卷 376, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.131941
关键词
Millettia speciosa Champ; NMR; UPLC-Q-TOF-MS metabolomics; Nonalcoholic fatty liver disease; Growth stages
资金
- High-level Talents Program of Basic and Applied Basic Research (Natural Science) for Hainan [2019RC307]
- Central Pubic-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences [1630032020044]
- Open project of Key Laboratory of South Tropical Plant Diversity for Shenzhen and Agricultural Wild Plant Resources Protection Project of the Ministry of Agriculture and Rural Affairs
- Beijing Municipal Reform and Development [2021ZL0122]
This study systematically evaluated the metabolomic profiling of Millettia speciosa root extracts at different growth stages. Significant differences were found among extracts from different ages, and 110 compounds were identified. Pharmacological studies suggested that 5-year old roots may have better fat-lowering and hepatoprotective effects, which could be beneficial for improving NAFLD.
Millettia speciosa Champ (M. speciosa) is an edible food and folk medicine and extracts from its roots exhibit a hepatoprotective effect. However, its metabolic growth process and the best harvest time have not been reported. This study systematically evaluated the metabolomic profiling of M. speciosa root extracts at different growth stages through the UPLC-Q-TOF-MS, nuclear magnetic resonance (NMR) and An orthogonal partial least squares-discriminant analysis (OPLS-DA). The results revealed there were significant differences among extracts from six ages of M. speciosa, and 110 compounds were identified. Pharmacological studies showed that 5-year and 20-year old M. speciosa roots may exhibit higher fat-lowering effects, while 5-year-old (M.s-5Y) showed better hepatoprotective activity in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) mice. Hence, our study suggested that M.s-5Y may have potent efficacy in ameliorating NAFLD, which might be useful in determining the optimum time to harvest M. speciosa.
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