期刊
FOOD CHEMISTRY
卷 378, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.132127
关键词
Anti-tyrosinase; Antioxidant; Antibacterial; Antibrowning; Gallic acid
资金
- National Key R&D Program of China [2018YFC1602205]
- National Natural Science Foundation of China [31972188]
- Guangdong Basic and Applied Basic Research Foundation [2020A1515110960, 2020A1515110326]
- Innovation Program of Shanghai Municipal Education Commission [2017-01-07-00-10E00056]
A series of gallic acid-benzylidenehydrazine hybrids were synthesized and evaluated for their tyrosinase inhibitory activity. Two compounds, 5d and 5f, showed potent inhibition and also exhibited antioxidant and antibacterial activities, making them potential candidates for novel food preservatives.
A series of gallic acid-benzylidenehydrazine hybrids were synthesized and evaluated for their tyrosinase inhibitory activity. Thereinto, compounds 5d and 5f potently inhibited tyrosinase with IC50 of 15.3 and 3.3 mu M, compared to kojic acid (44.4 mu M). The inhibition mechanism suggested that 5d and 5f not only chelated with Cu2+, but also reduced Cu2+ to Cu1+ in the tyrosinase active site. Additionally, 5d and 5f exhibited strong DPPH scavenging and antibacterial activities against Vibrio parahaemolyticu and Staphylococcus aureus, which can be attributed to the function of gallic acid and hydrazone moiety. These compounds also exhibited capacity to preserve fresh-cut apples and shrimps. Finally, 5d and 5f exhibited low cytotoxic activity in a human cell line (HEK293). Therefore, these compounds possess anti-tyrosinase, antioxidant, and antibacterial activities, and can be used in the development of novel food preservatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据