期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 161, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2022.112818
关键词
Di(2-ethylhexyl) phthalate; Heart; Mitochondrial damage; Mitophagy; Mitochondrial biogenesis
资金
- National Natural Science Foundation of China [32172932]
- Key Program of Natural Science Foundation of Heilongjiang Province of China [ZD2021C003]
- China Agriculture Research System of MOF [CARS-35]
- China Agriculture Research System of MARA [CARS-35]
- Distinguished Professor of Longjiang Scholars Support Project [T201908]
- Heilongjiang Touyan Innovation Team Program
This study investigated the mechanism by which DEHP causes heart damage in quail. The results showed that DEHP induced heart damage and mitochondrial damage, which were associated with dysregulation of mitochondrial biogenesis.
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used in agricultural and industrial plastic products. Many researchers have demonstrated that DEHP can cause varying degrees of harm to the heart. This research investigated the mechanism by which DEHP causes heart damage in quail. The quail were treated with DEHP (250 mg/kg BW/day, 500 mg/kg BW/day or 750 mg/kg BW/day) for 45 days. The present study suggested that DEHP could cause varying levels of heart damage, including disordered myocardial fiber arrangements, myocardial fiber breakage and myocardial cell swelling. The results showed that DEHP induced mitochondrial damage, such as cavitation lesions and mitochondrial crest breakage. DEHP damaged mitochondria and inhibited nuclear respiratory factor 1 (Nrf1)-mediated mitochondrial biogenesis, which led to mitochondrial damage. DEHP caused oxidative stress in the heart and activated the defense mechanism of the nuclear factor red blood cell 2 related factor 2 (Nrf2) system. DEHP-induced mitophagy was related to a decline in mitochondrial biogenesis and disordered mitochondrial dynamics. The data indicated that DEHP exposure damaged cardiac mitochondria and caused mitophagy and cardiotoxicity. Of note, this study showed that DEHP-induced mitophagy and mitochondrial damage are associated with the dysregulation of mitochondrial biogenesis.
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