期刊
FLY
卷 16, 期 1, 页码 152-176出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336934.2022.2061834
关键词
Interorgan communication; peripheral tissues; peptide hormones; ecdysone; juvenile hormone; innate behaviour; growth; metabolism; post-mating responses; reproduction
资金
- 10th Tomizawa Jun-ichi & Keiko Fund of Molecular Biology Society of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20K22645]
- Grants-in-Aid for Scientific Research [20K22645] Funding Source: KAKEN
This article summarizes recent advances in understanding target organs/tissues and functions of peripherally derived peptide hormones in Drosophila, and describes how these hormones contribute to various biological events through interorgan communications.
In multicellular organisms, endocrine factors such as hormones and cytokines regulate development and homoeostasis through communication between different organs. For understanding such interorgan communications through endocrine factors, the fruit fly Drosophila melanogaster serves as an excellent model system due to conservation of essential endocrine systems between flies and mammals and availability of powerful genetic tools. In Drosophila and other insects, functions of neuropeptides or peptide hormones from the central nervous system have been extensively studied. However, a series of recent studies conducted in Drosophila revealed that peptide hormones derived from peripheral tissues also play critical roles in regulating multiple biological processes, including growth, metabolism, reproduction, and behaviour. Here, we summarise recent advances in understanding target organs/tissues and functions of peripherally derived peptide hormones in Drosophila and describe how these hormones contribute to various biological events through interorgan communications.
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