期刊
FLUID PHASE EQUILIBRIA
卷 555, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fluid.2021.113348
关键词
Natural deep eutectic solvent; poly (propylene) glycol; ABS; phase compositions; drug partitioning, fructose
资金
- Tabriz research council
Natural deep eutectic solvents (NADESs) have attracted attention in aqueous biphasic systems (ABSs). In this study, a biodegradable ABS was prepared and its properties were investigated through experiments and models. The ABS exhibited behavior similar to a ternary system. In addition, the partitioning performance of the ABS for commonly used drugs was studied.
Natural deep eutectic solvents (NADESs) have gained a lot of attention in several fields and different applications, including separation of bio-molecules by aqueous biphasic system (ABS) containing these solvents. ABSs are well-known as green and non-toxic systems which are very important in pharmaceutical industry and drug extraction. In this work, a biodegradable ABS countering poly (propylene) glycol 400 and mixtures of choline chloride as hydrogen bond acceptor, HBA, and fructose, as hydrogen bond donor, HBD, with different molar ratios of choline chloride to fructose (i.e. 2:1 and 1:1) was made at T = 298.15 K and atmospheric pressure (approximate to 85 kPa). The measured binodal data were fitted by two semi-empirical Merchuk and Zafarani-Moattar et al. equations. To see the effect of molar ratio of NADES on position of binodal, the experimental binodal data were also treated with binodal model. Compositions of five tie-lines for each molar ratio for this ABS were carefully determined to see whether the created ABS is a ternary system or the hydrogen bonding between NADES component is destroyed and a quaternary system is formed. The results suggest that, with dissolving these complexes in aqueous solutions the HBA: HBD stoichiometry used in NADES preparation are approximately preserved in the phases in equilibrium and the ABS act as a ternary-like system. The NRTL and UNIQUAC models were selected to correlate the tie-lines. Also, the performance of these ABSs to partitioning of some commonly used drugs, namely lamotrigine, salicylic acid and acetaminophen were investigated by calculation of partition coefficients, K, and extraction efficiencies, EE %, at different tie-lines. The trend showed that the hydrophobicity of mentioned drugs is responsible for partitioning of these drugs preferentially into the polymer-rich top phase. Finally, the equation proposed by Diamond-Hsu and its modified form were used to correlate the drugs experimental partition coefficients in the studied ABS system. (C) 2021 Elsevier B.V. All rights reserved.
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