期刊
FITOTERAPIA
卷 157, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2022.105129
关键词
Tabernaemontana corymbosa; Indole alkaloid; Antibacterial activity; Streptococcus dysgalactiae
资金
- National Natural Science Foundation of China [31900290, 32000274]
- Yunnan Province Young Academic and Technical Leaders Project [202105AC160078]
- Yunnan Province Post-doctoral Project, Yunnan Province Education Department Scientific Research Fund Project [2020J0139]
- Applied Basic Research Key Project of Yunnan [202001AY070001-017]
- seventh batch of Yunnan specialty plant polysaccharide engineering research center
Tabernaecorymine A, a novel alkaloid compound obtained from the stem bark of Tabernaemontana corymbosa, exhibited significant antibacterial activity against Streptococcus dysgalactiae, with a better performance than the commonly used plant drug berberine.
Tabernaecorymine A, an 18-normonoterpenoid indole alkaloid with conjugated (E)-3-aminoacrylaldehyde fragment was obtained from the stem bark of Tabernaemontana corymbosa. Its structure was elucidated by extensive spectroscopic data analyses, and further verified by ACD/structure elucidator, electronic circular dichroism (ECD) analyses and density functional theory (DFT) chemical shift predictions. The compound exhibited significant antibacterial bioactivity against Streptococcus dysgalactiae with an MIC value of 3.12 mu g/mL, which is better than the plant drug berberine.
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