期刊
FISH & SHELLFISH IMMUNOLOGY
卷 125, 期 -, 页码 48-53出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2022.05.001
关键词
Phospholipase A/acyltransferases; p53; Protein interaction; Autophagy; Apoptosis; Zebrafish
资金
- National Natural Science Foundation of China [U21A20268, 32030112]
- National Key R&D Program of China [2018YFD0900302]
The study found that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism. However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that the plaat1 gene was constitutively expressed in tissues including liver, kidney, spleen, intestine, eye and brain, with relative higher expression levels detected in the brain and eye. Overexpression of plaat1 led to inhibition of p53 and tnf alpha mRNA expression. Furthermore, it was shown that PLAAT1 interacted with p53 to facilitate p53 degradation via autophagy-lysosome dependent pathway. Our work indicates that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
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