期刊
FEBS LETTERS
卷 596, 期 17, 页码 2305-2313出版社
WILEY
DOI: 10.1002/1873-3468.14404
关键词
amphisomes; autophagy; endomembranes; lipids; non-canonical autophagy; secretory pathway; vacuolar degradation; vesicle trafficking
资金
- European Research Council (ERC) under the European Union [948996, GZ: UE188/2-1]
- Deutsche Forschungsgemeinschaft
- European Research Council (ERC) [948996] Funding Source: European Research Council (ERC)
Autophagy plays a crucial role in plant cellular homeostasis by recycling cellular components. Recent studies have revealed the interconnection between autophagy and canonical membrane trafficking pathways, leading to a better understanding of the inner workings of both pathways in plant cells.
Autophagy fulfills a crucial role in plant cellular homeostasis by recycling diverse cellular components ranging from protein complexes to whole organelles. Autophagy cargos are shuttled to the vacuole for degradation, thereby completing the recycling process. Canonical autophagy requires the lipidation and insertion of ATG8 proteins into double-membrane structures, termed autophagosomes, which engulf the cargo to be degraded. As such, the autophagy pathway actively contributes to intracellular membrane trafficking. Yet, the autophagic process is not fully considered a bona fide component of the canonical membrane trafficking pathway. However, recent findings have started to pinpoint the interconnection between classical membrane trafficking pathways and autophagy. This review details the latest advances in our comprehension of the interplay between these two pathways. Understanding the overlap between autophagy and canonical membrane trafficking pathways is important to illuminate the inner workings of both pathways in plant cells.
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