期刊
FEBS JOURNAL
卷 289, 期 5, 页码 1156-1159出版社
WILEY
DOI: 10.1111/febs.16395
关键词
cancer epigenetics; chromatin; DNA methylation; histone modifications; transcriptional regulation
This Special Issue of The FEBS Journal, Cancer Epigenetics, features a collection of review articles that focus on the functions of a broad spectrum of epigenetic modulators in cancer. The topics explored in these articles range from the roles of transposable elements and chromatin architecture in cancer, to the effects of altered epigenetics on transcription and advanced cancer cell phenotypes. The potential of epigenetics for targeted cancer therapeutics is also discussed.
Over the past few decades, epigenetic regulators have emerged as major players in cellular processes that drive cancer initiation and progression, and subsequently modulate the responsiveness of cancers to therapeutic agents. This Special Issue of The FEBS Journal, Cancer Epigenetics, features an exciting collection of review articles that focus on the functions of a broad spectrum of epigenetic modulators in cancer. The diverse topics explored herein range from the roles of transposable elements and chromatin architecture in cancer and the most recent research advances on cancer-associated histone variants (oncohistones), to the effects of altered epigenetics on transcription and advanced cancer cell phenotypes. Moreover, the prospective key function of cancer metabolism in linking epigenetics and transcriptional regulation, and the potential of epigenetics for targeted cancer therapeutics is discussed. We hope that this collection of articles will give readers an enlightening overview of the most recent advances in the fast-moving field of cancer epigenetics.
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