相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors
Christine Brotherton-Pleiss et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3)
Qiuyao Huang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
An update on investigational therapies that target STAT3 for the treatment of cancer
Matteo Santoni et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
Dingding Gao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
Isidora Tosic et al.
NEOPLASIA (2021)
PROTACs technology for targeting non-oncoproteins: Advances and perspectives
Chao Wang et al.
BIOORGANIC CHEMISTRY (2021)
Discovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide
Xuebao Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation
Jinyun Dong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
LL1, a novel and highly selective STAT3 inhibitor, displays anti-colorectal cancer activities in vitro and in vivo
Zhe Liu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Qiuyao Huang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism
Lu Lu et al.
CELL PROLIFERATION (2020)
Allosteric inhibitors of the STAT3 signaling pathway
Junhong Qin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3
Rizhen Huang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization
Jan Jamroskovic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Uddalak Bharadwaj et al.
PHARMACOLOGICAL REVIEWS (2020)
Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3
Linlin Chen et al.
PHARMACOLOGICAL RESEARCH (2020)
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Jesse J. Balic et al.
NATURE COMMUNICATIONS (2020)
Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3 (vol 36, pg 6627, 2017)
T. Zhang et al.
ONCOGENE (2019)
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Longchuan Bai et al.
CANCER CELL (2019)
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein
Haibin Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
Tianyi Wang et al.
CELL METABOLISM (2018)
Design, synthesis and activity of BBI608 derivatives targeting on stem cells
Qifan Zhou et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development
Jacopo Sgrignani et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer
Yue Chen et al.
JOURNAL OF DRUG TARGETING (2018)
Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
Bettina Wingelhofer et al.
LEUKEMIA (2018)
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Daniel E. Johnson et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
CavityPlus: a web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction
Youjun Xu et al.
NUCLEIC ACIDS RESEARCH (2018)
AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses
Min Huang et al.
NUCLEIC ACIDS RESEARCH (2018)
Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors
Francisco Lopez-Tapia et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer
Xiaoxia Jiang et al.
CANCER MANAGEMENT AND RESEARCH (2018)
Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target
U. Saini et al.
ONCOGENE (2017)
Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
Xin Cheng et al.
ONCOTARGET (2017)
Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy
Tingting Feng et al.
ONCOTARGET (2017)
Improved Method for the Identification and Validation of Allosteric Sites
Kun Song et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking
Wenying Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152
Yu Wang et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Targeted protein degradation by PROTACs
Taavi K. Neklesa et al.
PHARMACOLOGY & THERAPEUTICS (2017)
STAT3 in cancer: A double edged sword
Lidia Avalle et al.
CYTOKINE (2017)
Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor
Joleen M. Hubbard et al.
DRUGS (2017)
Strategies and Approaches of Targeting STAT3 for Cancer Treatment
Stefanie L. Furtek et al.
ACS CHEMICAL BIOLOGY (2016)
Small-Molecule PROTACS: New Approaches to Protein Degradation
Momar Toure et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors
Matthew G. LaPorte et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Small-molecule kinase inhibitors: an analysis of FDA-approved drugs
Peng Wu et al.
DRUG DISCOVERY TODAY (2016)
Mitochondrial Stat3, the Need for Design Thinking
Rui Yang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)
Preclinical Characterization of 3β-(N-Acetyl L-cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer
Zilma Escobar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations
Jessica L. Geiger et al.
ORAL ONCOLOGY (2016)
Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species Conservation
Declan Clarke et al.
STRUCTURE (2016)
Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors
Steffanie L. Furtek et al.
ONCOTARGET (2016)
HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)
A STAT inhibitor patent review: progress since 2011
Ping-Shan Lai et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2015)
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma
Gabriella Miklossy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity
Tiancen Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity
Claudia Mertens et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway
Peng Ji et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
Kodappully Sivaraman Siveen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)
Haijun Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature
Antonio Lavecchia et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2014)
Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells
Nicholas Don-Doncow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Hua Yu et al.
NATURE REVIEWS CANCER (2014)
Allosite: a method for predicting allosteric sites
Wenkang Huang et al.
BIOINFORMATICS (2013)
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy
Haijun Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design
Wenying Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
IL-26 Promotes the Proliferation and Survival of Human Gastric Cancer Cells by Regulating the Balance of STAT1 and STAT3 Activation
Wei You et al.
PLOS ONE (2013)
Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents
Haijun Chen et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Caveolin-1 silencing arrests the proliferation of metastatic lung cancer cells through the inhibition of STAT3 signaling
Fabia Pancotti et al.
CELLULAR SIGNALLING (2012)
Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
Amir Sonnenblick et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2012)
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
Heehyoung Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells
Li Lin et al.
CANCER RESEARCH (2011)
Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
Steven Fletcher et al.
CHEMMEDCHEM (2011)
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
Inbal Hazan-Halevy et al.
BLOOD (2010)
A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells
Li Lin et al.
NEOPLASIA (2010)
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
ZL Yuan et al.
SCIENCE (2005)
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation
J Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Signal transducer and activator of transcription proteins in leukemias
M Benekli et al.
BLOOD (2003)
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation
DL Hevehan et al.
BLOOD (2002)
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
J Turkson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition of interleukin-6 signaling by galiellalactone
M Weidler et al.
FEBS LETTERS (2000)
STAT proteins and transcriptional responses to extracellular signals
CM Horvath
TRENDS IN BIOCHEMICAL SCIENCES (2000)
The biology of Stat4 and Stat6
AL Wurster et al.
ONCOGENE (2000)