☆ 4.3 Review

A comparison of the safety, feasibility, and tolerability of ECT and ketamine for treatment-resistant depression

EXPERT OPINION ON DRUG SAFETY (2022)

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Article Substance Abuse

Media coverage about medical benefits of MDMA and ketamine affects perceived likelihood of engaging in recreational use

Joseph J. Palamar et al.

Summary: Media coverage about the medical benefits of ketamine and MDMA may influence specific subsets of people to use these drugs, as shown by survey results from adults in nightclubs in New York City. Some participants reported an increased likelihood of using ketamine and MDMA in response to media coverage, indicating a potential impact of media on recreational drug use.

ADDICTION RESEARCH & THEORY (2022)

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Article Psychiatry

Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial

Eleanor J. Cole et al.

Summary: Stanford Neuromodulation Therapy (SNT), a high-dose intermittent theta-burst stimulation (iTBS) protocol with functional-connectivity-guided targeting, has shown promising efficacy in the treatment of treatment-resistant depression.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Editorial Material Clinical Neurology

Which first-generation antipsychotics should be repurposed for the treatment of schizophrenia

Stefan Leucht et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022)

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Article Obstetrics & Gynecology

A ketamine package for use in emergency cesarean delivery when no anesthetist is available: An analysis of 401 consecutive operations

Thomas F. Burke et al.

Summary: Trained non-anesthetist providers can safely use the ESM-Ketamine package to support emergency cesarean sections when no anesthetist is available, increasing the possibility of emergency cesarean deliveries in resource-limited settings.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2022)

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Article Clinical Neurology

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT)

Joakim Ekstrand et al.

Summary: This study compared the effectiveness of ketamine and electroconvulsive therapy (ECT) in treating depression. The results indicated that ketamine, although inferior to ECT, can still be a safe and valuable tool for treating severe depression.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2022)

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Editorial Material Clinical Neurology

Electroconvulsive therapy: still the gold standard for highly treatment-resistant mood disorders

Joseph F. Goldberg

CNS SPECTRUMS (2022)

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Article Behavioral Sciences

Electroconvulsive Therapy in Canada During the First Wave of COVID-19 Results of the What Happened National Survey

Ilya Demchenko et al.

Summary: The COVID-19 pandemic has significantly disrupted the provision of electroconvulsive therapy (ECT) services in Canada, leading to a decrease in delivery and even a complete suspension in some centers. There is a wide variability in decision-making, highlighting the need for a rational approach to offering ECT in pandemic contexts.

JOURNAL OF ECT (2022)

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Article Clinical Neurology

A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings

L. Alison McInnes et al.

Summary: This study examined the treatment response of depression patients receiving KIT in community practices. The results showed that more than half of the patients exhibited a treatment response after induction, and approximately one-third achieved remission. KIT has a significant antidepressant effect, but a small percentage of patients experienced worsening symptoms.

JOURNAL OF AFFECTIVE DISORDERS (2022)

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Article Psychology, Clinical

Cognitive Behavioral Therapy, Ketamine, and Combination Treatment for Depression: Impressions of Credibility in Participants with Self-Reported Depressive Symptoms

Mitch Earleywine et al.

Summary: The study found that participants viewed the combination treatment as more credible than ketamine, but not as effective as CBT alone. Participants rated the credibility of CBT significantly higher than ketamine, and those with psychotherapy experience were more cautious about ketamine. This suggests that providing detailed descriptions of treatments can influence potential clients' perceptions of their credibility.

JOURNAL OF PSYCHOACTIVE DRUGS (2022)

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Article Substance Abuse

Characteristics and circumstances of death related to the self-administration of ketamine

Shane Darke et al.

Summary: Based on the recorded cases in Australia, the typical case of self-administered ketamine-related death is a middle-aged male who used multiple drugs in a private setting, with accidental drug toxicity as the most common cause of death. These cases often involve a combination of different substances, highlighting the prevalence of polydrug use.

ADDICTION (2021)

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Review Clinical Neurology

Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis

Anees Bahji et al.

Summary: The study showed that intravenous racemic ketamine was more effective and better tolerated than intranasal esketamine for the treatment of unipolar and bipolar major depression.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Neurosciences

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

Danilo De Gregorio et al.

Summary: A resurgence of interest in hallucinogens for the treatment of psychiatric disorders has emerged, with studies confirming the efficacy of ketamine in treating depression. Emerging evidence also suggests potential therapeutic properties of psilocybin, LSD, and MDMA for mental diseases.

JOURNAL OF NEUROSCIENCE (2021)

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Article Psychiatry

Efficacy, safety and tolerability of formula-based unilateral vs bilateral electroconvulsive therapy in the treatment of major depression: A randomized open label controlled trial

Monika Dominiak et al.

Summary: This study compared formula-based right unilateral ECT with fronto-temporal bilateral ECT in treating patients with bipolar or unipolar depression. The two types of ECT showed no significant difference in antidepressant efficacy, but formula-based RUL ECT had advantages in terms of safety and tolerability.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Article Geriatrics & Gerontology

Right unilateral versus bilateral formula-based electroconvulsive therapy in the treatment of major depression in elderly patients: a randomised, open label, pilot controlled trial

Monika Dominiak et al.

Summary: The study aimed to compare the efficacy, safety, and tolerability of formula-based right unilateral (RUL) and fronto-temporal bilateral (BT) ECT in elderly depressed patients. The results showed that ECT was highly effective and safe among elders, with RUL ECT not differing from BT in antidepressant efficacy but having cognitive advantages.

PSYCHOGERIATRICS (2021)

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Letter Medicine, Research & Experimental

Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)

Pascal Urwyler et al.

Summary: The study aims to investigate the efficacy and safety of conestat alfa in COVID-19 patients with pulmonary disease. It is an investigator-initiated, multicenter randomized controlled trial.

TRIALS (2021)

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Article Behavioral Sciences

Subanesthetic dose of ketamine for the antidepressant effects and the associated cognitive impairments of electroconvulsive therapy in elderly patients-A randomized, double-blind, controlled clinical study

Lei Zou et al.

Summary: The study found that low-dose ketamine as an adjunct anesthetic for elderly patients undergoing ECT is safe and effective, reducing memory deficits and accelerating antidepressant effects.

BRAIN AND BEHAVIOR (2021)

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Article Psychiatry

Ketamine treatment for depression: qualitative study exploring patient views

Sagar Jilka et al.

Summary: Patients are enthusiastic about ketamine treatment but need more information before national roll-out. The wider societal impact of ketamine treatment also needs to be considered and patients need to be part of any future roll-out to ensure its success.

BJPSYCH OPEN (2021)

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Article Psychiatry

Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial

Jennifer B. Dwyer et al.

Summary: This study demonstrated that intravenous ketamine has significant short-term efficacy in reducing depressive symptoms in adolescents with depression, as well as being well tolerated acutely. Compared to an active placebo, ketamine resulted in a significant reduction in depressive symptoms within 24 hours of treatment.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Review Clinical Neurology

Is ketamine an appropriate alternative to ECT for patients with treatment resistant depression? A systematic review

Jolien K. E. Veraart et al.

Summary: Studies suggest that ketamine treatment may provide faster but possibly less durable antidepressant effects compared to ECT, with less cognitive impairment as a potential advantage. Methodologically well-designed studies with larger sample sizes and longer follow-up durations are needed to further evaluate the efficacy and safety of ketamine as an alternative treatment for patients with TRD.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Review Psychiatry

The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders: A systematic review and meta-analysis

Jiaqi Xiong et al.

Summary: The study aimed to evaluate the acute anti-suicidal ideation effects of single-dose ketamine in different formulations and routes of administration by pooling the results from randomized controlled trials. The findings suggest that intravenous ketamine and intranasal esketamine are associated with robust reductions in suicidal thoughts at 2-h, 4-h, and 24-h post-intervention. Further research on intramuscular, oral, and sublingual ketamine, as well as comparative studies, are needed to evaluate the efficacy of these formulations and routes of administration in reducing suicidal ideation.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Editorial Material Psychiatry

Electroconvulsive Therapy Is an Essential Procedure COMMENT

Daniel F. Maixner et al.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Article Psychiatry

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

Roger S. McIntyre et al.

Summary: Replicated international studies have highlighted the human and societal costs of major depressive disorder, with monoamine-based antidepressants proving effective but many patients failing to fully recover. Ketamine and esketamine offer novel pharmacological treatments for treatment-resistant depression, but questions remain about their safety and effectiveness. International experts provide guidance on the use of these agents, while discussing areas of consensus and future research directions.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Review Behavioral Sciences

Electroconvulsive Therapy in Children and Adolescents A Systematic Review of Current Literature and Guidelines

Erik Dossing et al.

Summary: This study evaluated the efficacy of electroconvulsive therapy (ECT) in children and adolescents with major psychiatric diseases, concluding that while the overall level of evidence is low, ECT should be considered in severe cases. High-quality studies are needed to further assess the efficacy of ECT in potentially life-threatening diseases.

JOURNAL OF ECT (2021)

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Review Psychiatry

The effectiveness, safety and tolerability of ketamine for depression in adolescents and older adults: A systematic review

Joshua D. Di Vincenzo et al.

Summary: This article summarizes the literature on the effectiveness, safety, and tolerability of ketamine treatment for depression in different age groups. While most studies focus on adult populations, there is less research on adolescents and older adults. Although ketamine shows promising rapid antidepressant effects, the limited quantity and generally low quality of available studies restricts statistical syntheses and conclusions.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Review Neurosciences

The Neurobiological Basis of Cognitive Side Effects of Electroconvulsive Therapy: A Systematic Review

Adriana Bassa et al.

Summary: Decades of research have shown the efficacy of electroconvulsive therapy (ECT) in treating major depressive disorder (MDD), but its cognitive side effects have limited its clinical use. Studies suggest that ECT-related cognitive side effects are not caused by neural cell damage mechanisms, and some protein concentrations and gene polymorphisms have been proposed as potential predictive biomarkers of cognitive dysfunction after ECT. Recent advancements in brain imaging have also helped identify ECT-induced changes in brain structures related to memory performance.

BRAIN SCIENCES (2021)

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Review Psychology, Clinical

Overgeneral and specific autobiographical memory predict the course of depression: an updated meta-analysis

D. J. Hallford et al.

Summary: The study found that overgeneral memory can predict the course of depressive symptoms, with generally small effects, but significantly larger effects in clinical samples. Older age may be associated with stronger effects, while longer follow-up may be associated with weaker effects. Results on other moderating variables were mixed.

PSYCHOLOGICAL MEDICINE (2021)

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Article Psychiatry

Relapse after abrupt discontinuation of maintenance electroconvulsive therapy during the COVID-19 pandemic

Simon Lambrichts et al.

Summary: Objective Maintenance electroconvulsive therapy (M-ECT) is effective in preventing relapse in severe mood and psychotic disorders, but there is insufficient research on how long to continue M-ECT and the outcome after discontinuation. A study in a psychiatric hospital found that nearly half of patients experienced relapse within 6 months of abruptly stopping M-ECT, with factors like previous ECT courses, diagnosis of psychotic disorder, and shorter interval between treatments at discontinuation increasing the risk of relapse.

ACTA PSYCHIATRICA SCANDINAVICA (2021)

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Article Psychiatry

Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients

Taeho Greg Rhee et al.

Summary: In this observational study, ECT was found to be associated with lower 1-year all-cause mortality and temporary protective effects on suicide risk. The study suggests that ECT may be a beneficial consideration for inpatients with mood disorders at short-term risk of suicide.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Article Psychiatry

Mortality after electroconvulsive therapy

Bradley Watts et al.

Summary: The study showed that there was no evidence of elevated or excess mortality after ECT. Patients receiving ECT had a lower risk of all-cause mortality in the year after their index course of ECT compared to similar patients who did not receive ECT.

BRITISH JOURNAL OF PSYCHIATRY (2021)

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Article Clinical Neurology

Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders

Felicia Ceban et al.

Summary: The emerging roles of ketamine and esketamine as effective rapid-acting antidepressants offer hope for patients with treatment-resistant depression, but practitioners need to be familiar with common adverse events and strategies for prevention and management to reduce patient burden.

CNS DRUGS (2021)

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Review Geriatrics & Gerontology

Electroconvulsive Therapy in Elderly Patients With Cerebral Aneurysms: A Systematic Review With Clinical Recommendations

Syed Muhammad Ahsan Mehdi et al.

Summary: In elderly patients undergoing ECT with cerebral aneurysms, there is a risk of complications related to hypertension, emphasizing the need for appropriate safety measures. Risk factors such as history of hypertension and patient age should be carefully managed to prevent adverse outcomes.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2021)

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Article Psychiatry

Neurocognitive Effects of Ketamine and Esketamine for Treatment-Resistant Major Depressive Disorder: A Systematic Review

Breno Souza-Marques et al.

Summary: This study systematically reviewed the neurocognitive effects of ketamine and esketamine in patients with treatment-resistant major depressive disorder, finding that these drugs do not seem to have significant deleterious effects on cognitive function and certain brain areas, and may even be beneficial for patients.

HARVARD REVIEW OF PSYCHIATRY (2021)

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Article Psychiatry

Practical recommendations for the management of treatment-resistant depression with esketamine nasal spray therapy: Basic science, evidence-based knowledge and expert guidance

Siegfried Kasper et al.

Summary: Esketamine nasal spray is a novel, fast-acting agent that offers an additional treatment option for treatment-resistant depression patients who have not responded to previous therapies. The expert guidance in this manuscript provides practical recommendations for clinicians to consider during the treatment process.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2021)

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Review Psychiatry

The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Recommendations for the Use of Racemic Ketamine in Adults with Major Depressive Disorder: Recommandations Du Groupe De Travail Du Reseau Canadien Pour Les Traitements De L'humeur Et De L'anxiete (Canmat) Concernant L'utilisation De La Ketamine Racemique Chez Les Adultes Souffrant De Trouble Depressif Majeur

Jennifer Swainson et al.

Summary: Ketamine, particularly when administered intravenously, has rapid antidepressant effects for patients with treatment-resistant depression. Consensus recommendations cover clinical administration, dosages and monitoring for IV ketamine.

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2021)

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Article Neurosciences

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

Olga Therese Ousdal et al.

BIOLOGICAL PSYCHIATRY (2020)

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Review Psychiatry

Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials

Katrina Witt et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2020)

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Review Psychology, Clinical

Defining treatment-resistant depression

Bradley N. Gaynes et al.

DEPRESSION AND ANXIETY (2020)

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Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study

Fernanda S. Correia-Melo et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Clinical Neurology

Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression

Elia E. Acevedo-Diaz et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Neurosciences

Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression

Jennifer L. Phillips et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Substance Abuse

Substance use disorders and risk for treatment resistant depression: a population-based, nested case-control study

Philip Brenner et al.

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A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

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AMERICAN JOURNAL OF PSYCHIATRY (2020)

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Kevin M. Bozymski et al.

ANNALS OF PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

Maurizio Fava et al.

MOLECULAR PSYCHIATRY (2020)

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Effects of video psychoeducation on perceptions and knowledge about electroconvulsive therapy

Jack Tsai et al.

PSYCHIATRY RESEARCH (2020)

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Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant

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BEHAVIOURAL BRAIN RESEARCH (2020)

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Esketamine for treatment resistant depression: a trick of smoke and mirrors?

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EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2020)

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Article Psychiatry

Antidepressant and neurocognitive effects of serial ketamine administration versus ECT in depressed patients

Laura Basso et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2020)

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Article Pharmacology & Pharmacy

Safety and tolerability of IV ketamine in adults with major depressive or bipolar disorder: results from the Canadian rapid treatment center of excellence

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A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol

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BMC PSYCHIATRY (2020)

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The use of ketamine to cope with depression and post-traumatic stress disorder: A qualitative analysis of the discourses posted on a popular online forum

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A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

Paulo R. Shiroma et al.

TRANSLATIONAL PSYCHIATRY (2020)

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Editorial Material Behavioral Sciences

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Phern Chern Tor et al.

JOURNAL OF ECT (2020)

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Article Chemistry, Medicinal

Safety of Repeated Administration of Parenteral Ketamine for Depression

David Feifel et al.

PHARMACEUTICALS (2020)

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Article Psychiatry

ECT in the time of the COVID-19 pandemic

Venkata Subramanian Ramakrishnan et al.

AUSTRALASIAN PSYCHIATRY (2020)

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Article Psychiatry

Post-Marketing Safety Concerns with Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System

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PSYCHOTHERAPY AND PSYCHOSOMATICS (2020)

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Article Clinical Neurology

Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression

Paulo R. Shiroma et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Multidisciplinary Sciences

The role of dissociation in ketamine's antidepressant effects

Elizabeth D. Ballard et al.

NATURE COMMUNICATIONS (2020)

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Review Behavioral Sciences

Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder

Caroline E. Strong et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)

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Article Psychiatry

Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine's antidepressant effects

Valerie J. Sydnor et al.

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Ketamine treatment for individuals with treatment-resistant depression: longitudinal qualitative interview study of patient experiences

Karen Lascelles et al.

BJPSYCH OPEN (2020)

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Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2)

Ewa Wajs et al.

JOURNAL OF CLINICAL PSYCHIATRY (2020)

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The Long and Winding Road of Vagus Nerve Stimulation: Challenges in Developing an Intervention for Difficult-to-Treat Mood Disorders

Harold A. Sackeim et al.

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Article Pharmacology & Pharmacy

Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers

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THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2020)

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Meeting Abstract Clinical Neurology

Patients with major depressive disorder have lower cerebral serotonin 4 receptor binding than healthy controls

K. Koehler-Forsberg et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2020)

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Long-term subjective memory after electroconvulsive therapy

Robert Sigstrom et al.

BJPSYCH OPEN (2020)

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Letter Clinical Neurology

Is (S)-norketamine an alternative antidepressant for esketamine?

Kenji Hashimoto et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2019)

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Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial

Dawn F. Ionescu et al.

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ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol

Sanjay J. Mathew et al.

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Neurognitive function and symptom remission 2 years after ECT in major depressive disorders

Christine Mohn et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Article Geriatrics & Gerontology

MMSE Changes During and After ECT in Late-Life Depression: A Prospective Study

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AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2019)

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A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial

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Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats

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Soren D. Ostergaard et al.

ANESTHESIOLOGY (2019)

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Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children

Sojin Park et al.

PLOS ONE (2019)

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Review Anesthesiology

Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy A Systematic Review and Meta-analysis

Andreas Duma et al.

ANESTHESIOLOGY (2019)

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Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case Series of Patients With Depression and Alcohol Use Disorder

Gihyun Yoon et al.

JAMA PSYCHIATRY (2019)

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Review Psychiatry

An Overview of Reviews on the Safety of Electroconvulsive Therapy Administered During Pregnancy

Shana Coshal et al.

JOURNAL OF PSYCHIATRIC PRACTICE (2019)

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Review Psychiatry

Cognitive function following a major depressive episode: a systematic review and meta-analysis

Maria Semkovska et al.

LANCET PSYCHIATRY (2019)

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Article Psychiatry

Exploring patients' and carers' views about the clinical use of ketamine to inform policy and practical decisions: mixed-methods study

Sagar Jilka et al.

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Electroconvulsive Therapy in Children and Adolescents: Clinical Indications and Special Considerations

Nicole M. Benson et al.

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Influence of depressed patients' expectations prior to electroconvulsive therapy on its effectiveness and tolerability (Exp-ECT): a prospective study

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Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO World Mental Health (WMH) surveys

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PSYCHOLOGICAL MEDICINE (2018)

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Article Psychiatry

Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial

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AMERICAN JOURNAL OF PSYCHIATRY (2018)

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Article Psychiatry

The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis

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AMERICAN JOURNAL OF PSYCHIATRY (2018)

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Article Clinical Neurology

Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression

Mark J. Niciu et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

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Article Clinical Neurology

Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions

Patricio Riva-Posse et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

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Review Behavioral Sciences

Patient Experience of Electroconvulsive Therapy A Retrospective Review of Clinical Outcomes and Satisfaction

Sarah K. Brown et al.

JOURNAL OF ECT (2018)

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Review Behavioral Sciences

Treatment resistant depression: A multi-scale, systems biology approach

Huda Akil et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

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Identifying Recipients of Electroconvulsive Therapy: Data From Privately Insured Americans

Samuel T. Wilkinson et al.

PSYCHIATRIC SERVICES (2018)

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Article Psychiatry

Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States

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JAMA PSYCHIATRY (2018)

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Review Biochemistry & Molecular Biology

Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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A Meta-Analysis of the Association Between Patients' Early Perception of Treatment Credibility and Their Posttreatment Outcomes

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PSYCHOTHERAPY (2018)

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Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

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NEUROPSYCHOPHARMACOLOGY (2017)

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ECT-Related Anxiety A Systematic Review

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Analysis of print news media framing of ketamine treatment in the United States and Canada from 2000 to 2015

Melvyn W. B. Zhang et al.

PLOS ONE (2017)

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Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway

Xinran Li et al.

ONCOTARGET (2017)

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Association of Electroconvulsive Therapy With Psychiatric Readmissions in US Hospitals

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JAMA PSYCHIATRY (2017)

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Article Psychiatry

A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders

Gerard Sanacora et al.

JAMA PSYCHIATRY (2017)

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Review Psychiatry

The mortality rate of electroconvulsive therapy: a systematic review and pooled analysis

N. Torring et al.

ACTA PSYCHIATRICA SCANDINAVICA (2017)

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Review Pediatrics

Depression in children and young people: identification and management in primary, community and secondary care (NICE guideline CG28)

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ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION (2016)

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Electroconvulsive therapy and cognitive functions in treatment-resistant depression

Anna Bodnar et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2016)

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Article Psychiatry

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression

Jaskaran B. Singh et al.

AMERICAN JOURNAL OF PSYCHIATRY (2016)

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Editorial Material Psychiatry

Potential Risks of Poorly Monitored Ketamine Use in Depression Treatment

Kathryn M. Schak et al.

AMERICAN JOURNAL OF PSYCHIATRY (2016)

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Article Clinical Neurology

Based on a True Story? The Portrayal of ECT in International Movies and Television Programs

Pascal Sienaert

BRAIN STIMULATION (2016)

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Review Psychiatry

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly

Glenda M. MacQueen et al.

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2016)

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Editorial Material Psychiatry

Updated CANMAT Guidelines for Treatment of Major Depressive Disorder

Scott B. Patten

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2016)

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Review Psychology, Clinical

KETAMINE FOR TREATMENT-RESISTANT UNIPOLAR AND BIPOLAR MAJOR DEPRESSION: CRITICAL REVIEW AND IMPLICATIONS FOR CLINICAL PRACTICE

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DEPRESSION AND ANXIETY (2016)

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Editorial Material Behavioral Sciences

The FDA and ECT

William M. McDonald et al.

JOURNAL OF ECT (2016)

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Review Behavioral Sciences

A Systematic Review of the Safety of Electroconvulsive Therapy Use During the First Trimester of Pregnancy

Katherine Calaway et al.

JOURNAL OF ECT (2016)

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Article Psychiatry

The efficacy and safety of ECT in population before and after 60 years of age

Anna Antosik-Wojcinska et al.

PSYCHIATRIA POLSKA (2016)

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Article Psychology, Clinical

Choosing Medications for Treatment-Resistant Depression Based on Mechanism of Action

Michael E. Thase et al.

JOURNAL OF CLINICAL PSYCHIATRY (2015)

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Review Psychiatry

Electroconvulsive therapy during pregnancy: a systematic review of case studies

Kari Ann Leiknes et al.

ARCHIVES OF WOMENS MENTAL HEALTH (2015)

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Article Neurosciences

Neurocognitive Effects of Ketamine and Association with Antidepressant Response in Individuals with Treatment-Resistant Depression: A Randomized Controlled Trial

James W. Murrough et al.

NEUROPSYCHOPHARMACOLOGY (2015)

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Article Substance Abuse

Intensive Ketamine Use for Multiple Years: A Case Report

James X. Liu et al.

AMERICAN JOURNAL ON ADDICTIONS (2015)

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Article Clinical Neurology

Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression

Paulo R. Shiroma et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2014)

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Article Clinical Neurology

Do the dissociative side effects of ketamine mediate its antidepressant effects?

David A. Luckenbaugh et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

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Article Neurosciences

Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring

Tianyun Zhao et al.

NEUROBIOLOGY OF DISEASE (2014)

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Ketamine prevents stress-induced cognitive inflexibility in rats

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PSYCHONEUROENDOCRINOLOGY (2014)

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Article Neurosciences

Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response

James W. Murrough et al.

PSYCHOPHARMACOLOGY (2014)

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Review Psychology, Clinical

Cognitive impairment in depression: a systematic review and meta-analysis

P. L. Rock et al.

PSYCHOLOGICAL MEDICINE (2014)

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Review Primary Health Care

Prevalence of treatment-resistant depression in primary care: cross-sectional data

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BRITISH JOURNAL OF GENERAL PRACTICE (2013)

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Periadolescent Exposure to the NMDA Receptor Antagonist MK-801 Impairs the Functional Maturation of Local GABAergic Circuits in the Adult Prefrontal Cortex

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JOURNAL OF NEUROSCIENCE (2013)

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Article Medicine, General & Internal

Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test

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The prevalence and natural history of urinary symptoms among recreational ketamine users

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Neural mechanisms of the cognitive model of depression

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NATURE REVIEWS NEUROSCIENCE (2011)

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Review Neurosciences

Continuation and Maintenance Electroconvulsive Therapy for Mood Disorders: Review of the Literature

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NEUROPSYCHOBIOLOGY (2011)

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Review Neurosciences

Objective Cognitive Performance Associated with Electroconvulsive Therapy for Depression: A Systematic Review and Meta-Analysis

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BIOLOGICAL PSYCHIATRY (2010)

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Review Anesthesiology

The evolution of ketamine applications in children

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PEDIATRIC ANESTHESIA (2010)

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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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SCIENCE (2010)

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Review Clinical Neurology

What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies

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JOURNAL OF AFFECTIVE DISORDERS (2009)

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The Quick Inventory of Depressive Symptomatology-Self-report: a psychometric evaluation in patients with asthma and major depressive disorder

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ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2008)

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Article Substance Abuse

Journey through the K-hole: Phenomenological aspects of ketamine use

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Review Geriatrics & Gerontology

The effects of ECT on cognitive functioning in the elderly: a review

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INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2008)

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Cognitive processing speed and the structure of white matter pathways: Convergent evidence from normal variation and lesion studies

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NEUROIMAGE (2008)

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Editorial Material Pediatrics

What is the evidence for the safety and efficacy of using ketamine in children?

G. Dolansky et al.

PAEDIATRICS & CHILD HEALTH (2008)

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Attentional bias to incentive stimuli in frequent ketamine users

C. J. A. Morgan et al.

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The creation of the concept of an antidepressant: An historical analysis

Joanna Moncrieff

SOCIAL SCIENCE & MEDICINE (2008)

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Psychiatric safety of ketamine in psychopharmacology research

Edward B. Perry et al.

PSYCHOPHARMACOLOGY (2007)

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Article Psychiatry

All-cause mortality among recipients of electroconvulsive therapy - Register-based cohort study

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BRITISH JOURNAL OF PSYCHIATRY (2007)

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Article Neurosciences

The cognitive effects of electroconvulsive therapy in community settings

Harold A. Sackeim et al.

NEUROPSYCHOPHARMACOLOGY (2007)

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Article Psychiatry

Electroconvulsive therapy and transcranial magnetic stimulation: Can they be considered valid modalities in the treatment of pediatric mood disorders?

Daniel Stein et al.

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA (2006)

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Article Psychiatry

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Carlos A. Zarate et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

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Article Neurosciences

Behavioral effects of ketamine and toxic interactions with psychostimulants

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BMC NEUROSCIENCE (2006)

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Practice parameter for use of electroconvulsive therapy with adolescents

[Anonymous]

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2004)

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Article Clinical Neurology

Rumination and executive function in depression: an experimental study

E Watkins et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2002)

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Review Psychology, Clinical

A review of the nonmedical use of ketamine: Use, users and consequences

KLR Jansen

JOURNAL OF PSYCHOACTIVE DRUGS (2000)

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Electroconvulsive therapy and memory loss: A personal journey

AB Donahue

JOURNAL OF ECT (2000)

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Antidepressant effects of ketamine in depressed patients

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BIOLOGICAL PSYCHIATRY (2000)

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