☆ 4.6 Review

New treatments and new assessment instruments for Hidradenitis suppurativa

EXPERIMENTAL DERMATOLOGY (2022)

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Letter Dermatology

Identification of clinical features affecting diagnostic delay in paediatric hidradenitis suppurativa: results from a multicentre observational study

Antonella Di Cesare et al.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Validation of global item for assessing impact on quality of life of patients with hidradenitis suppurativa

J. S. Kirby et al.

Summary: This study confirms the reliability and validity of a candidate single-item PtGA in assessing HS-specific HRQoL. The PtGA exhibited convergent and known-groups validity when administered alongside other patient-reported scales. It also showed good test-retest reliability and responsiveness to change for patients with HS.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R): psychometric property assessment

N. Goldfarb et al.

Summary: Results from the clinometric assessment of the HASI-R are promising, with moderate inter-rater reliability and high intra-rater reliability, good construct validity, and known-groups validity. The HASI-R was also the most preferred tool by all raters.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Letter Dermatology

Pain Index: a new prospective hidradenitis suppurativa patient-reported outcome measure instrument

C. C. Zouboulis

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: Results of a prospective European cohort study

Kelsey R. van Straalen et al.

Summary: The study demonstrated significant efficacy of both oral tetracycline treatment and clindamycin plus rifampicin combination therapy for patients with hidradenitis suppurativa after 12 weeks. There were no significant differences in efficacy between the two treatments, regardless of disease severity.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Editorial Material Dermatology

Hidradenitis suppurativa-specific, patient-reported outcome measures

C. C. Zouboulis et al.

Summary: The study by R. Sommer et al. published in the Journal of the European Academy of Dermatology and Venereology in 2021 focused on a specific topic in the field of dermatology.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Dermatology

Real-world effectiveness of adalimumab in patients with moderate-to-severe hidradenitis suppurativa: the 1-year SOLACE study

W. Gulliver et al.

Summary: The study found that patients with moderate and high AN counts achieved better results at 24 and 52 weeks of treatment with adalimumab, with gender and age at onset affecting treatment effectiveness. The use of adalimumab led to a decrease in lesions, especially in inflammatory nodules, and the IHS4 scores of responders were substantially lowered. No new safety issues were detected during the treatment and observation period.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Dermatology

Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa A Phase 2, Double-blind, Placebo-Controlled Randomized Clinical Trial

Sophie Glatt et al.

Summary: In this study, bimekizumab showed clinically meaningful improvements in patients with moderate to severe HS, demonstrating greater efficacy compared to placebo. The safety profile of bimekizumab was consistent with previous studies, supporting further evaluation for HS treatment.

JAMA DERMATOLOGY (2021)

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Article Surgery

Efficacy and Safety of Adalimumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa The SHARPS Randomized Clinical Trial

Falk G. Bechara et al.

Summary: The study investigated the efficacy and safety of adalimumab in combination with surgery for hidradenitis suppurativa, showing that adalimumab can improve clinical response by 14% across all body regions postoperatively. There was no increased risk of adverse events such as infection, complication, or hemorrhage with adalimumab compared to placebo after surgery.

JAMA SURGERY (2021)

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Article Dermatology

Severity and Area Score for Hidradenitis (SASH): a novel outcome measurement for hidradenitis suppurativa

J. S. Kirby et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Letter Dermatology

Hidradenitis Suppurativa Area and Severity Index (HASI): a pilot study to develop a novel instrument to measure the physical signs of hidradenitis suppurativa

N. Goldfarb et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

The Hidradenitis Suppurativa Quality of Life (HiSQOL) score: development and validation of a measure for clinical trials

J. S. Kirby et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

Adalimumab Dose Intensification in Recalcitrant Hidradenitis Suppurativa/Acne Inversa

Christos C. Zouboulis et al.

DERMATOLOGY (2020)

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Letter Dermatology

Patients with hidradenitis suppurativa may suffer from neuropathic pain: A Finnish multicenter study

Laura Huilaja et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Review Dermatology

Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

A. G. Vaiopoulos et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Editorial Material Dermatology

Chronic Pain in Hidradenitis Suppurativa Explained Through the Process of Central Sensitization

Kelsey R. van Straalen

JAMA DERMATOLOGY (2020)

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Article Medicine, General & Internal

Hidradenitis suppurativa

Robert Sabat et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Medicine, General & Internal

Prevalence of Neuropathic Pain and Related Characteristics in Hidradenitis Suppurativa: A Cross-Sectional Study

Simone Garcovich et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Dermatology

Hidradenitis suppurativa/acne inversa: a practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group

C. C. Zouboulis et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Review Dermatology

Patient-reported outcomes in hidradenitis suppurativa

Gautham Vellaichamy et al.

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA (2019)

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Article Dermatology

Inter-rater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa

L. Thorlacius et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Article Dermatology

Clinical Characteristics of Pruritus and Pain in Patients with Hidradenitis Suppurativa

Lukasz Matusiak et al.

ACTA DERMATO-VENEREOLOGICA (2018)

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Article Dermatology

A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process

L. Thorlacius et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Dermatology

Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II

L. Thorlacius et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Multidisciplinary Sciences

Factors associated with patient recall of key information in ambulatory specialty care visits: Results of an innovative methodology

M. Barton Laws et al.

PLOS ONE (2018)

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Article Dermatology

Quality of life considerations and pain management in hidradenitis suppurativa

Gregor B. E. Jemec

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY (2017)

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Article Medicine, General & Internal

Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes

Linnea Thorlacius et al.

BMJ OPEN (2017)

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Article Dermatology

Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity

C. C. Zouboulis et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

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Review Dermatology

Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process

J. R. Ingram et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Article Medicine, General & Internal

Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa

Alexa B. Kimball et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Dermatology

Assessing the validity, responsiveness and meaningfulness of the Hidradenitis Suppurativa Clinical Response (HiSCR) as the clinical endpoint for hidradenitis suppurativa treatment

A. B. Kimball et al.

BRITISH JOURNAL OF DERMATOLOGY (2014)

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Letter Dermatology

Hidradenitis suppurativa markedly decreases quality of life and professional activity

Lukasz Matusiak et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2010)

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Article Public, Environmental & Occupational Health

An integrative model of shared decision making in medical encounters

G Makoul et al.

PATIENT EDUCATION AND COUNSELING (2006)

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