4.6 Article

Significance of a tumor microenvironment-mediated P65-miR-30a-5p-BCL2L11 amplification loop in multiple myeloma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression

Antonio G. Solimando et al.

Summary: The interaction between malignant multiple myeloma (MM) plasma cells and the microenvironment, particularly bone marrow MM endothelial cells expressing junctional adhesion molecule-A (JAM-A), plays a crucial role in regulating MM progression. Elevated expression of JAM-A in MM endothelial cells is associated with poor clinical outcomes and advanced disease. Blocking JAM-A has shown to restrict angiogenesis and impede MM progression, suggesting it as a potential therapeutic target for halting neo-angiogenesis in MM.

HAEMATOLOGICA (2021)

Article Biochemistry & Molecular Biology

miR-218 contributes to drug resistance in multiple myeloma via targeting LRRC28

Haifei Chen et al.

Summary: This study investigated the role and molecular mechanism of miRNAs in multiple myeloma, revealing that aberrant expression of miR-218 contributes to drug resistance in MM by targeting LRRC28, suggesting LRRC28 as a potential therapeutic target for MM.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

Review Oncology

The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression

Almudena Garcia-Ortiz et al.

Summary: Multiple myeloma is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow, with disease progression influenced by the tumor microenvironment created by various cells and soluble factors. Understanding the elements that control the microenvironment could lead to better-targeted therapies for this incurable disease.

CANCERS (2021)

Article Oncology

Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression

Alissa Visram et al.

Summary: Immunotherapy efficacy in relapsed multiple myeloma may be influenced by the tumor immune microenvironment, which was found to become progressively dysfunctional with therapy. The study also suggests that the MM clone may be less dependent on inflammation-mediated growth pathways and less sensitive to IFN-mediated immunosurveillance. This could explain the decreased sensitivity of triple-refractory MM patients to novel immunotherapies.

BLOOD CANCER JOURNAL (2021)

Review Cell Biology

Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma

Alessandro Allegra et al.

Summary: The prognosis of patients with multiple myeloma has improved, but many still experience relapse and drug resistance. MicroRNAs play a role in regulating gene expression and modulating their activity may help in reversing drug resistance.
Review Biochemistry & Molecular Biology

The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma

Nikolaos Giannakoulas et al.

Summary: Significant progress has been made in developing therapies for multiple myeloma, but it remains incurable. Research has shed light on the genetic background of malignant plasma cells and the crucial role of the bone marrow microenvironment. The interaction between myeloma cells and components of the microenvironment is considered essential in the pathogenesis of multiple myeloma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

HMGB1 enhances chemotherapy resistance in multiple myeloma cells by activating the nuclear factor-κB pathway

Jing Ning et al.

Summary: Chemotherapy resistance is a major challenge in the treatment of multiple myeloma (MM). The study revealed that HMGB1 regulates drug resistance in MM cells by modulating the NF-kappa B signaling pathway, indicating its potential as a therapeutic target for MM.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Oncology

Magnolol suppressed cell migration and invasion and induced cell apoptosis via inhibition of the NF-κB signaling pathway by upregulating microRNA-129 in multiple myeloma

Weimei Jin et al.

Summary: This study found that magnolol can inhibit migration and invasion of multiple myeloma (MM) cells, promote cell apoptosis by regulating miR-129. Magnolol suppresses cell migration and invasion, induces cell apoptosis by inhibiting NF-kappa B pathway activation, and upregulating miR-129 in MM cells.

NEOPLASMA (2021)

Article Medicine, Research & Experimental

PKCζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds

Jian Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Oncology

Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth

Emanuela Leone et al.

CLINICAL CANCER RESEARCH (2013)