期刊
EUROPEAN RESPIRATORY JOURNAL
卷 60, 期 4, 页码 -出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/13993003.02395-2021
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资金
- Swedish Research Council [K2005-72X-11242-11A, K2008-69X-20826-01-4]
- Swedish Child Diabetes Foundation (Barndiabetesfonden)
- JDRF Wallenberg Foundation [K 98-99D-12813-01A]
- Medical Research Council of Southeast Sweden (FORSS)
- Swedish Council for Working Life and Social Research [FAS2004-1775]
- Ostgota Brandstodsbolag
- UK Medical Research Council
- Wellcome [217065/Z/19/Z]
- University of Bristol
- Swedish Heart Lung Foundation
- ALF Region Stockholm
- SFO Epidemiology Karolinska Institutet
- European Research Council [757919, ERC-2014-CoG-648916]
- Programme Grants for Applied Research funding scheme [RP-PG-0407-10044]
- Wellcome Trust [WT101597MA]
- Swiss National Science Foundation [320030_163311, SNF: 320030-182628, 320030-162820, 3233-069348, 3200-069349]
- Italian Ministry of Health
- Lundbeck Foundation [R16-A1694, 195/04, R100-A9193, R264-2017-3099]
- Ministry of Health [903516]
- Danish Council for Strategic Research [0603-00280B]
- Capital Region Research Foundation
- Danish National Research Foundation
- Danish Regional Committees
- Egmont Foundation
- March of Dimes Birth Defects Foundation
- Novo Nordisk Foundation
- Danish Medical Research Council [SSVF 0646, 271-08-0839/06-066023, O602-01042B, 0602-02738B]
- Innovation Fund Denmark [0603-00294B (09-067124)]
- Nordea Foundation [02-2013-2014]
- University of Copenhagen
- Danish Council for Independent Research [DFF-4183-00594, DFF-4183-00152]
- Foundation for Medical Research (FRM)
- National Institute for Research in Public health
- French Ministry of Health (DGS)
- French Ministry of Research
- INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs
- French National Institute for Health Education (INPES)
- European Union [733206]
- Diabetes National Research Program
- Mutuelle Generale de l'Education Nationale complementary health insurance (MGEN)
- French national agency for food security
- European Community [261357]
- Erasmus MC Rotterdam
- Erasmus University Rotterdam
- Netherlands Organisation for Health Research and Development [2001-1-1322]
- ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) [696295]
- Netherlands Organisation for Health Research and Development (ZonMw) [529051014, 2100.0090]
- Science Foundation Ireland [SFI/16/ERA-HDHL/3360]
- European Union's Horizon 2020 research and innovation programme [733206, 824989, 874583]
- European Regional Development Fund (ERDF) through the Operational Programme Competitiveness and Internationalization
- Foundation for Science and Technology (FCT), Portuguese Ministry of Science, Technology and Higher Education
- Unidade de Investigacao em Epidemiologia-Instituto de Saude Publica da Universidade do Porto (EPIUnit) [UIDB/04750/2020]
- Fundacao Calouste Gulbenkian
- FCT [IF/01060/2015]
- Federal Ministry for Education, Science, Research and Technology (interventional arm)
- Helmholtz Zentrum Muenchen
- Norwegian Research Council [226402]
- Instituto de Salud Carlos III (FEDER funds) [FIS-PI09/00090, FIS-PI18/01142]
- CIBERESP, Dept of Health of the Basque Government [2013111089]
- Instituto de Salud Carlos III (including FEDER funds) [Red INMA G03/176, CB06/02/0041, 97/0588, 00/0021-2, PI061756, PS0901958, PI14/00677]
- CIBERESP
- EC [QLK4-CT-200-00263]
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041, PI041436, PI081151, CP16/00128]
- Generalitat de Catalunya-CIRIT [1999SGR 00241]
- Fundacio La marato de TV3 [090430]
- European Social Fund Investing in your future
- Spain: Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]
- FIS-FEDER [PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, Miguel Servet-FEDERCP11/00178, CP15/00025, CPII16/00051]
- Generalitat Valenciana: FISABIO [UGP 15-230, UGP-15-244, UGP-15-249]
- Alicia Koplowitz Foundation
- Asthma UK [364, 07/048]
- Isle of Wight NHS Trust
- British Medical Association
- Netherlands Asthma Foundation [3.2.03.48, 3.2.07.022]
- Health Research Board, Ireland
- Irish Dept of Health and Children's Health Promotion Policy Unit
- Federal Ministry for Education, Science, Research and Technology
- Helmholtz Centre for Environmental Research-UFZ, Leipzig
- Federal Ministry for Environment (IUF Duesseldorf) [FKZ 20462296]
- Commission of the European Communities
- European Research Council under the European Union [949906]
- Child and Youth Health Care Zuyderland
- Public Health Service South Limburg
- Juho Vainio Foundation
- EVO/VTR
- Paeivikki and Sakari Sohlberg Foundation
- Farmers' Social Insurance Institution (Mela)
- Finnish Cultural Foundation
- Foundation for Pediatric Research
- Finnish Institute for Health and Welfare, Finland
- German Research Foundation (DFG) [KE1462/2-1]
- Economic and Social Research Council
- consortium of UK government
- Welcome Trust [187389/B/08/Z]
- Norwegian Ministry of Health and Care Services
- Research Council of Norway through its Centres of Excellence [262700]
- Compagnia San Paolo Foundation
- INSERM
- French National Research Agency
- Fondation de France
- French Agency for Food, Environmental and Occupational Health Safety
- French Ministry of Labour
- National Science Center Poland [DEC-2014/15/B/N27/00998]
- European Union Social Fund
- Hellenic Ministry of Health [MIS 349580]
- National Institute of Environmental Health Sciences (NIEHS) [R01ES030691, R01ES029944, R01ES030364, R21ES029681, R21ES028903, P30ES007048]
- University of Turku
- Abo Akademi University
- Foundation for Pediatric Research Finland
- British Heart Foundation
- Arthritis Research UK
- NIHR Southampton Biomedical Research Centre
- GlaxoSmithKline Netherlands
- University Medical Center Utrecht (UMCU)
- Pharmacy Foundation
- Health Foundation
- Aarhus Ideas [AU R9-A959-13-S804]
- National Agency for Research (ANR)
- Paris-Sud University
- Nestle
- French National Institute for Population Health Surveillance (InVS)
- French Association of Diabetic Patients (AFD)
- ANSES
- French speaking association for the study of diabetes and metabolism (ALFEDIAM)
- Dept of the Environment of the Flemish Government
- Flemish Agency of Care and Health
- Flemish Dept of Economy, Science and Innovation
- Administracao Regional de Saude Norte (Regional Dept of Ministry of Health)
- Beca de la IV convocatoria de Ayudas a la Investigacion en Enfemerdades Neurodegeneratives de La Caixa
- National Institutes of Health USA [R01HL082925]
- Research Institute at Marien-Hospital Bad Honnef
- Maastricht University
- Academy of Finland [139021, 287675, 296814, 296817, 308254, 123571, 140251, 277535]
- German Federal Ministry of Education and Research (MBMF) [07015633m 07ALE27, 01EE9405/5, 01EE9406]
- Ministry of Education and Research
- French Ministry of Ecology
- Netherlands Organisation of Health Research and Development
- Netherlands Organisation for Scientific Research
- Netherlands Asthma Fund
- Netherlands Ministry of Spatial Planning, Housing and the Environment
- Netherlands Ministry of Health, Welfare and Sport
- Turku University Hospital
- Medical Research Council
- Food Standards Agency
- Swiss National Science Foundation (SNF) [320030_182628, 320030_163311] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [949906] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [287675, 296814, 296817, 308254, 308254, 296817, 296814] Funding Source: Academy of Finland (AKA)
- Science Foundation Ireland (SFI) [16/ERA-HDHL/3360] Funding Source: Science Foundation Ireland (SFI)
Early-life lower respiratory tract infections may increase the risk of asthma and lower lung function in school-age children. The study also found that early-life lower respiratory tract infections have the strongest impact on respiratory diseases in children with wheezing.
Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4-15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: -0.09 (95% CI -0.14- -0.04) to -0.30 (95% CI -0.36- -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98-2.22) to 6.30 (95% CI 5.64-7.04) and 1.25 (95% CI 1.18-1.32) to 1.55 (95% CI 1.47-1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
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