期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 59, 期 -, 页码 58-67出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2022.04.003
关键词
Cannabidiol; Cannabinoids; Anxiety disorders; Therapeutics
资金
- ZonMW
- Dutch Brain Foundation, Programme Translational Research [40-41, 200-98-9269]
- Department of Experimental Psychology, Utrecht University
Preclinical research suggests that enhancing CB1 receptor agonism may improve fear extinction. However, a clinical trial examining the use of cannabidiol (CBD) as an adjunctive therapy in anxiety disorders found that CBD did not improve treatment outcome or enhance fear extinction or extinction learning.
Preclinical research suggests that enhancing CB1 receptor agonism may improve fear extinction. In order to translate this knowledge into a clinical application we examined whether cannabidiol (CBD), a hydrolysis inhibitor of the endogenous CB1 receptor agonist anandamide (AEA), would enhance the effects of exposure therapy in treatment refractory patients with anxiety disorders. Patients with panic disorder with agoraphobia or social anxiety disorder were recruited for a double-blind parallel randomised controlled trial at three mental health care centres in the Netherlands. Eight therapist-assisted exposure in vivo sessions (weekly, outpatient) were augmented with 300 mg oral CBD (n = 39) or placebo (n = 41). The Fear Questionnaire (FQ) was assessed at baseline, mid-and post-treatment, and at 3 and 6 months follow-up. Primary analyses were on an intent-to-treat basis. No differences were found in treatment outcome over time between CBD and placebo on FQ scores, neither across (beta = 0.32, 95% CI [-0.60; 1.25]) nor within diagnosis groups (beta = -0.11, 95% CI [-1.62; 1.40]). In contrast to our hypotheses, CBD augmentation did not enhance early treatment response, within-session fear extinction or extinction learning. Incidence of adverse effects was equal in the CBD (n = 4, 10.3%) and placebo condition (n = 6, 15.4%). In this first clinical trial examining CBD as an adjunctive therapy in anxiety disorders, CBD did not improve treatment outcome. Future clinical trials may investigate different dosage regimens. (c) 2022 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据