期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 57, 期 -, 页码 1-14出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2021.12.011
关键词
NPY; CGRP; Neurokinin A; Neurotensin; Corticotropin releasing hormone; HAB LAB rats
资金
- Swedish MRC [10414]
- Karolinska Institutet
- Lundbeck Foundation
- Deutsche Forschungsgemeinschaft, Germany
- Alma Mater Studiorum University of Bologna [RFO2018]
This study compared the levels of neuropeptides relevant to anxiety and depression in different brain regions of high anxiety behavior (HAB) and low anxiety behavior (LAB) rats. The results showed that HAB rats had elevated levels of neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and neurotensin in various brain regions. These elevated levels were associated with increased anxiety and depression-like behaviors in the rats.
Anxiety disorders are pervasive psychiatric disorders causing great suffering. The high (HAB) and low (LAB) anxiety-related behaviour rats were selectively bred to investigate neurobiological correlates of anxiety. We compared the level of neuropeptides relevant for anxiety- and depression-related behaviours in selected brain regions of HAB and LAB rats. Increased anxiety and depression-like behaviours of male and female HAB rats in the elevated plus-maze and forced swim tests were accompanied by elevated levels of neuropeptide Y (NPY) in the prefrontal (PFC), frontal (FC) and cingulate cortex (CCx), the striatum, and periaqueductal grey (PAG). Moreover, HAB rats displayed sex-dependent, elevated levels of calcitonin gene-related peptide (CGRP) in PFC, FC, CCx, hippocampus, and PAG. Higher neurokinin A (NKA) levels were detected in CCx, striatum, and PAG in HAB males and in CCx and hypothalamus in HAB females. Increased neurotensin was detected in CCx and PAG in HAB males and in hypothalamus in HAB females. Elevated corticotropin-releasing hormone (CRH) levels appeared in female HAB hypothalamus. Significant correlations were found between anxiety-like behaviour and NPY, CGRP, NKA, and neurotensin, particularly with NPY in CCx and striatum, CGRP in FC and hippocampus, and NKA in entorhinal cortex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据