☆ 4.5 Editorial Material

Toward the helioscope hypothesis of psychedelic therapy

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

Analysis of recreational psychedelic substance use experiences classified by substance

Adrian Hase et al.

Summary: This study compared the linguistic profiles of different psychedelic drugs and found distinct effect profiles among them. The results offer valuable information for experimental research on psychedelic drugs in healthy populations and clinical trials for treating psychiatric problems.

PSYCHOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Jennifer M. Mitchell et al.

Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris et al.

Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Clinical Neurology