期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 924, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2022.174909
关键词
Antioxidant; Myocardial infarction; (-) Epicatechin; Lipid peroxidation; Isoproterenol; Troponin-I
资金
- Department of Science and Tech-nology (DST) -SERC Fast Track Scheme, Government of India, New Delhi [SR/FT/LS-021/2007]
This study assessed the preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and inflammation in myocardial infarction, and found that it improved cardiac function.
Myocardial infarction (MI) is a life-threatening condition. No studies were conducted earlier on the effects of (-) epicatechin (EC) on tachycardia, cardiac hypertrophy, and inflammation in MI. Hence, the preventive effects of EC on tachycardia, cardiac hypertrophy, and nuclear factor-kappa B inflammatory signaling pathway in experimental MI were appraised. This investigation included 4 groups of 24 male albino Wistar rats. Group:1. Normal control, Group: 2. EC (20 mg/kg body weight), Group: 3. Isoproterenol (100 mg/kg body weight), Group:4. EC (20 mg/kg body weight) + Isoproterenol (100 mg/kg body weight). MI was created in rats by isoproterenol (100 mg/kg body weight). The heart rate, heart weight, plasma myoglobin, serum cardiac troponin I, heart conjugated dienes, serum high-sensitivity C-reactive protein, and plasma total homocysteine were considerably (P < 0.05) raised in isoproterenol-induced myocardial infarcted rats. Further, reverse transcription-polymerase chain reaction study revealed a considerable (P < 0.05) increase in the expressions of heart pro-inflammatory cytokines such as nuclear factor-kappa B, tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and a considerable (P < 0.05) decrease in anti-inflammatory cytokine gene, interleukin-10 in myocardial infarcted rats. Non-enzymatic antioxidants such as vitamin C, and vitamin E were considerably (P < 0.05) lessened in the heart. EC (20 mg/kg body weight) pre-treatment orally, daily, for 3 weeks prevented all changes in the above-mentioned functional, structural, biochemical, and molecular parameters investigated and improved cardiac function. The possible mechanisms are EC's anti-tachycardial, anti-cardiac hypertrophic, antioxidant, and anti-inflammatory effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据