Biomimetic platelet membrane-coated nanoparticles for targeted therapy

The development of cell membrane-modified biomimetic nanoparticles has extensively increased during the past years due to their exceptional biocompatibility, evasion from the immune system, and targeting ability. Known as a cutting-edge area of research in nanomedicine, such novel nanoplatforms can mimic different functions of the primary cells, while successfully delivering their cargos to the defect site with the aim of enhancing the therapeutic responses and reducing the side effects. Platelet is a key factor for haemostasis and a major player in wound healing, inflammation, and many other biological functions and pathological conditions. As a highly responsive cell, platelets can adapt to environment modifications and release several soluble biomolecules, such as growth factors, coagulant factors, and extracellular vesicles. Additionally, platelets are capable of immune system evasion, sub-endothelial adhesion, and pathogen interaction. These characteristics have inspired the design of several platelet membrane-coated nanoparticles as drug delivery systems. This review describes the current developments in platelet membrane-coated nanoparticles for targeted therapy, specifically, their advantages compared to other biomimetic cell-derived nanoparticles and their applicability in the medical field are elucidated. Finally, the challenges and future perspectives associated with this nanoplatform are summarised.

Automated summary

The development of cell membrane-modified biomimetic nanoparticles, specifically platelet membrane-coated nanoparticles, has shown great potential in the field of nanomedicine for targeted therapy. These nanoparticles can mimic the functions of primary cells and successfully deliver drugs to the targeted sites, enhancing therapeutic responses and reducing side effects. Platelet membrane-coated nanoparticles possess the characteristics of platelets, including immune system evasion and interaction with pathogens, making them an ideal drug delivery system.