Is cannabidiol worth a trial in Rasmussen encephalitis?

We report 3 patients (age 8,13 and 14 years) with drug-resistant epilepsy due to Rasmussen encephalitis treated with cannabidiol in addition to their current antiseizure medication (ASM). In all three patients we observed a positive effect, which seemed to surpass the efficacy that would be expected from a different fourth or fifth antiseizure drug used during the course of the disease. (c) 2022 The Authors. Published by Elsevier Ltd on behalf of European Paediatric Neurology Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4. 0/).

Automated summary

This study reports the use of cannabidiol in three patients with drug-resistant Rasmussen encephalitis. Positive effects were observed in all three patients, exceeding the expected efficacy of other antiseizure drugs.