Natural Product Synthesis by Intramolecular Alkylidene Carbene C-H Insertion

Direct functionalization of unactivated C-H bonds is of increasing importance in organic synthesis. Of the many methods that have been developed, intramolecular alkylidene C-H insertion, proceeding with retention of absolute configuration, is among the most versatile. This Review explores all examples of the use of intramolecular alkylidene C-H insertion in natural product synthesis.

Automated summary

Direct functionalization of unactivated C-H bonds is becoming increasingly important in organic synthesis. Among the various methods, intramolecular alkylidene C-H insertion, which retains the absolute configuration, is one of the most versatile. This Review explores all examples of the use of intramolecular alkylidene C-H insertion in natural product synthesis.