New Mechanistic Insights into the Ru-Catalyzed Asymmetric Hydrogenation of β-Ketoesters

We describe the results of our quantum mechanical investigation of the asymmetric hydrogenation of beta-ketoesters catalyzed by [RuCl2(MeOH)(2)((R)-MeOBIPHEP)] (7 a), which is generated in situ from [Ru(OAc)(2)((R)-MeOBIPHEP)] (4 a) and HCl in methanol. Interestingly, HCl not only acts as an activator for 4 a as it has a dramatic effect on the reaction itself: While HCl/4 a=2 leads to rather poor results (36 % ee and 13 % conv. after 4 h at at a substrate-to-catalyst ratio (S/C)=50'000), HCl/4 a=20 results in high efficiency (>99.9 % conv.) and enantioselectivity (99 % ee favoring the opposite enantiomer) under otherwise identical conditions. The origin for this sweeping change in performance has remained a mystery for two decades. Here, we show for the first time that a highly selective HCl pathway becomes operational under acidic conditions, which outcompetes moderately selective pathways dominating under neutral conditions. Furthermore, we explain the effects of common phosphorus substituents on the activity of the catalyst.

Automated summary

This study investigates the asymmetric hydrogenation of beta-ketoesters catalyzed by [RuCl2(MeOH)(2)((R)-MeOBIPHEP)]. It is found that HCl acts as both an activator and has a significant impact on the reaction. The study also explains the effects of common phosphorus substituents on the activity of the catalyst.