期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2022, 期 16, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202101456
关键词
Green chemistry; Sulfonyl hydrazides; Sulfone propionic acid; Synthetic methods; Water
资金
- Natural Science Foundation of Shandong Province [2019GGX104021, ZR2020MB136, 2020GXRC014]
A water-promoted synthesis method for constructing 3-sulfone propionic acids from sulfonyl hydrazides and alpha, beta-unsaturated propionic acids with high yields was reported in this study. The green synthesis method was promoted by water without the need for any catalyst, ligand, or organic solvent. The D2O control experiment confirmed that the 2-hydrogen atom of 3-sulfone propionic acid is derived from water. Additionally, the 3-sulfone propionic acid derivatives can be directly purified by crystallization without column chromatography.
A water-promoted synthesis methodology for constructing 3-sulfone propionic acids from sulfonyl hydrazides and alpha, beta-unsaturated propionic acids with excellent yields were reported. The green synthesis methodology was promoted by water without any catalyst, ligand and organic solvent. The D2O control experiment sufficiently proved that the 2-hydrogen atom of 3-sulfone propionic acid come from water. Moreover, the 3-sulfone propionic acid derivates could be directly purified by crystallization without column chromatography.
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