期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 56, 期 9, 页码 5564-5586出版社
WILEY
DOI: 10.1111/ejn.15636
关键词
Alzheimer's disease animal model; Computational models; Network activity; neural circuits
资金
- National Institute of General Medical Sciences [T32 GM007356]
- National Science Foundation
- National Institute of Mental Health [MH113924]
- National Institute of Child Health and Human Development [P50 HD-20-016]
In this review, the importance of neural circuit research in Alzheimer's disease (AD) is discussed, with emphasis on synapses and network activity and how they contribute to our understanding of the disease process.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by behavioural changes that include memory loss and cognitive decline and is associated with the appearance of amyloid-beta plaques and neurofibrillary tangles throughout the brain. Although aspects of the disease percolate across multiple levels of neuronal organization, from the cellular to the behavioural, it is increasingly clear that circuits are a critical junction between the cellular pathology and the behavioural phenotypes that bookend these levels of analyses. In this review, we discuss critical aspects of neural circuit research, beginning with synapses and progressing to network activity and how they influence our understanding of disease processed in AD.
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