期刊
EUROPEAN JOURNAL OF NEUROLOGY
卷 29, 期 8, 页码 2289-2298出版社
WILEY
DOI: 10.1111/ene.15378
关键词
cerebral small vessel disease; fractal dimension; optical coherence tomography angiography; peripapillary retina nerve fiber layer; white matter hyperintensities
资金
- National Nature Science Foundation of China [82171385]
- Key Research and Development Program of Hubei Province [2020BCA070]
- Application Foundation Frontier Special Project of Wuhan Science and Technology Bureau [2020020601012226]
- Flagship Program of Tongji Hospital [2019CR106]
The study found that abnormalities in retinal microvascular density, morphological parameters, and PRNFL thickness are correlated with the incidence of moderate/severe WMHs, particularly DWMHs, suggesting that arteriosclerosis and hypoperfusion are the causes of DWMHs.
Background and purpose Whilst retinal microvasculature represents cerebral small vessels, the retinal nerve fiber layer is the extended white matter of the brain. The aim was to investigate the correlation between changes in retina and white matter hyperintensities (WMHs). Methods Sixty-four candidates with WMHs received an optical coherence tomography angiography examination. WMHs were divided into mild or moderate/severe groups according to the Fazekas score. After imaging the superficial capillary plexus (SCP) and deep capillary plexus (DCP), the microvascular density parameters (vascular perfusion density [VPD], vascular length density [VLD] and fovea avascular zone area) and morphological parameters (vessel diameter index [VDI], fractal dimension [FD] and vessel tortuosity) were identified. A software algorithm measured the thickness of the peripapillary retina nerve fiber layer (PRNFL). Results Thirty-two were classified as having mild WMHs and 32 were moderate/severe. The median (interquartile range) ages of the two groups were 58 (54-64) and 61 (57-67) years, respectively. A decrease of FD, VPD and VLD in either SCP or DCP appeared with an increased risk of moderate/severe WMHs. Although changes of capillary plexus were not associated with paraventricular WMHs, decreased FD, VPD, VLD and fovea avascular zone area in either SCP or DCP were associated with an increased risk of moderate/severe deep WMHs (DWMHs). Participants with moderate/severe WMHs demonstrated reduced PRNFL thickness, particularly in the DWMHs, compared with mild WMHs. Conclusions Abnormalities of retinal microvascular density, morphological parameters and PRNFL thickness are correlated with the incidence of moderate/severe WMHs, particularly the DWMHs, suggesting that arteriosclerosis and hypoperfusion are the causes of DWMHs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据